Isaac Kohane and his team at the Children's Hospital, Boston, US, collected umbilical cord tissue samples from 54 premature infants born at less than 28 weeks of gestation, including 20 samples from infants who later developed BPD.
When DNA expression profiles were compared, the researchers found that infants who subsequently developed BPD had distinct gene expression signatures that differed from the ones who did not develop the disease, although the maternal characteristics (for example, the cause of delivery, race, or inflammation of the uterus) were similar. The genes that differed between the two groups involved chromatin remodelling and histone acetylation pathways.
"This has provided a rare opportunity to examine the influence of foetal physiology on postnatal health and development using the multiple tissues in umbilical cords as a proxy for a wide variety of tissues in the maternal-foetal unit," says Kohane.
BPD occurs in 20-40% of infants born below 1000 grams and before 28 weeks of gestation, and means babies still need supplemental oxygen at 36 weeks postmenstrual age. It is the second leading cause of death among infants born within this gestational age and is characterised by inflammation and scarring in the lungs.
The study by Kohane and colleagues will contribute towards generating prognostic markers for disease from umbilical cord profiles.
Charlotte Webber | alfa
At last, butterflies get a bigger, better evolutionary tree
16.02.2018 | Florida Museum of Natural History
New treatment strategies for chronic kidney disease from the animal kingdom
16.02.2018 | Veterinärmedizinische Universität Wien
Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale
Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...
For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.
But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...
Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...
Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...
Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).
Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...
15.02.2018 | Event News
13.02.2018 | Event News
12.02.2018 | Event News
16.02.2018 | Information Technology
16.02.2018 | Health and Medicine
16.02.2018 | Physics and Astronomy