The protein has a crucial role in correctly targeting protein kinase A (PKA) to a molecular complex that helps control the rate and strength of heart muscle contractions.
This complex regulates the uptake of calcium into intracellular stores in the heart, allowing it to relax and prepare for its next contraction. PKA must be present for the complex to be activated and AKAP18 makes sure that it gets there.
Coronary artery disease leading to heart attacks, which can be acutely fatal or can induce heart failure resulting in death, is the biggest killer of men in the United States of America and Europe. With 10 million new cases of heart failure every year, approximately 30% of patients respond poorly to current treatments, with an ultimately fatal outcome. New drugs to improve survival from post-infarction heart failure are desperately needed. AKAP18 may prove to be an effective novel target in the fight to live beyond this deadly event.
Kjetil Taskén and co-workers hope that AKAP18 can be used as a potential drug target to improve the survival rate of patients with heart failure following heart-attacks, or sufferers of heritable heart disease. By targeting AKAP18, the team aims to specifically affect PKA and its regulatory complex when it is over-activated and help the heart to continue to function effectively.
Kjetil Taskén | alfa
Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory
How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.
Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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