Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

London School of Hygiene to play key role in global collaboration on adverse drug reactions

27.09.2007
The London School of Hygiene & Tropical Medicine is to be a key player in the first global research collaboration aimed at identifying the genetic markers related to Adverse Drug Reactions (ADRs).

The Serious Adverse Event Consortium (SAEC) is a non-profit global partnership between leading pharmaceutical companies, drug regulatory authorities and academic institutions aimed at identifying genetic markers that may help to predict which patients are at risk from adverse or serious drug reactions (ADRs). It will provide a global knowledge base about these genetic variations and will be a major step forward in the drive to develop and deliver safer medicines.

ADRs are important causes of illness, limit the usefulness of many otherwise effective drugs, and are under strong genetic influence. Identifying the genetic variants that may influence a patient’s susceptibility to ADRs will greatly improve our understanding of the risk and molecular basis of adverse drug reactions.

Dr. Mariam Molokhia, Clinical Lecturer at the London School of Hygiene & Tropical Medicine, will be one of the main UK investigators of the collaborative project, and will be working jointly with SAEC to address clinical and scientific issues and identify DNA-variants useful in predicting the risk of drug-related serious adverse events, including liver toxicity and other series ADRs.

... more about:
»ADR »Collaboration »adverse »reactions

Dr. Molokhia co-ordinates the EUDRAGENE project, a European collaboration to establish a case-control DNA collection for studying the genetic basis of adverse drug reactions. She comments: ‘Research in this area is hampered by a lack of resources. As most such ADRs are rare, a case-control design is the only feasible approach, and a multi-centre international collaboration is necessary as no single country will generate enough cases of any given ADR within a reasonable time. I am delighted that the London School of Hygiene & Tropical Medicine is going to be playing a key role in a project that will greatly improve our understanding of genetic variation in relation to drug safety’.

Lindsay Wright | alfa
Further information:
http://www.lshtm.ac.uk
http://www.eudragene.org

Further reports about: ADR Collaboration adverse reactions

More articles from Life Sciences:

nachricht Unique genome architectures after fertilisation in single-cell embryos
30.03.2017 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH

nachricht Transport of molecular motors into cilia
28.03.2017 | Aarhus University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

'On-off switch' brings researchers a step closer to potential HIV vaccine

30.03.2017 | Health and Medicine

Penn studies find promise for innovations in liquid biopsies

30.03.2017 | Health and Medicine

An LED-based device for imaging radiation induced skin damage

30.03.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>