Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mice teeth explain the troubles with human wisdom teeth

27.09.2007
During evolution, many of a species’ properties are shaped by ecological interactions. This is readily evident in mammalian teeth, whose many features closely reflect what each species eats.

However, for a long time scientists have suspected that genetic and developmental interactions may also influence species-specific properties.

Now, researchers at the University of Helsinki’s Institute of Biotechnology show how development affects the evolution of teeth, and have devised a simple developmental model to predict aspects of teeth across many species. The results were published in Nature.

In the study in the field of evolutionary developmental biology, the researchers Kathryn Kavanagh, Jukka Jernvall and Alistair Evans in the Institute of Biotechnology of the University of Helsinki first studied cheek tooth, or molar, development in mice. Similarly to human teeth, mouse molars develop from front-to-back so that the first molar appears first and the posterior molars bud sequentially along the jaw. Normally the last molar to develop is the third, or wisdom tooth. Experiments on cultured mouse molars revealed that the size and number of posterior molars depend on previously initiated molars.

... more about:
»Development »Evolution »WISDOM »teeth

The mechanism, called an ‘inhibitory cascade’, acts much like a ratchet that cumulatively increases size differences of teeth along the jaw. By quantifying their experiments, the researchers constructed a simple mathematical model which they then used to predict relative size and number of molars across many other mouse and rat species. They show that the model accurately predicts tooth proportions and numbers, one curious effect being that the second molar makes up one-third of total molar area, irrespective of species-specific molar proportions.

This new research demonstrates that with advances in the study of the molecular regulation of development, it is now possible to identify how development influences evolution. And this may help explain the troublesome wisdom teeth of modern humans - the blame may lie within a weak inhibitory cascade that allows the development of the last molar in a jaw that is too small.

The article Predicting evolutionary patterns of mammalian teeth from development by K. Kavanagh, J. Jernvall and A. Evans will be published in Nature September 27th.

Maria Peltonen | alfa
Further information:
http://www.helsinki.fi

Further reports about: Development Evolution WISDOM teeth

More articles from Life Sciences:

nachricht A novel socio-ecological approach helps identifying suitable wolf habitats
17.02.2017 | Universität Zürich

nachricht New, ultra-flexible probes form reliable, scar-free integration with the brain
16.02.2017 | University of Texas at Austin

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Biocompatible 3-D tracking system has potential to improve robot-assisted surgery

17.02.2017 | Medical Engineering

Real-time MRI analysis powered by supercomputers

17.02.2017 | Medical Engineering

Antibiotic effective against drug-resistant bacteria in pediatric skin infections

17.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>