"Nobody really knows why flu is a winter disease in the temperate regions and more continuous in the tropics," says Edward Holmes, professor of biology at Penn State. "The big question is, ‘Why is flu seasonal"’"
Flu infections in the Northern Hemisphere typically follow a familiar pattern. Some time before the start of the winter infection season, the virus evolves, changing enough to evade the previously primed immune system. Then, just before summer, the virus disappears, only to resurface the next fall with a completely different genetic makeup, ready to fool the immune system anew.
But little is known about what happens to the virus between two successive winters, or how and where it is able to sustain itself.
The key question, Holmes explains, is whether the virus settles into a dormant state waiting for the right cues of temperature and sunlight to reactivate, or whether it migrates to viral reservoirs in the tropics, from where it is later reintroduced.
It is thought that places in Southeast Asia, where humans and animals live in close proximity, might be the permanent melting pot where viruses continually circulate and exchange genetic information.
To test the migration theory, Holmes and Martha Nelson, graduate student at Penn State, and their colleagues at the National Institutes of Health, Lone Simonsen, Cecile Viboud, and Mark A. Miller, analyzed the influenza A virus genomes of 900 virus samples from New Zealand, Australia and New York state dating between 1998-2005.
Their findings, outlined in this month's issue of PLoS Pathogens, reveal that the genomes of 52 viruses from New York are closely related to viruses that circulate during the winter (April to October) in New Zealand and Australia. These mixed family trees of viruses from both the north and south suggest there is widespread viral traffic across the equator each season, which contributes significantly to new epidemics in both hemispheres, the researchers note.
"If the viruses had been dormant, samples from successive seasons in each region would only be closely related to other viruses of that same region," said Holmes, who is also affiliated with Penn State's Center for Infectious Disease Dynamics (CIDD). "The fact that they are, instead, interspersed clearly tells us that the viruses are seasonally migrating across both hemispheres."
However, it is still fully unclear where and when the viruses are evolving to beat the immune system. According to Nelson, the virus changes its entire genetic makeup somewhere during the summer off-season, and it likely does this in the tropics, where the virus is found year-round.
"But we cannot say for sure at this point. To test this theory, we need viral samples from the tropics," Nelson added. The authors anticipate that samples from these regions will become available in the next few years.
The researchers are also not sure why the virus seems to die out during summer and what exactly triggers its return.
"It could be anything from human migration, aspects of climate, levels of sunlight, seasonal susceptibility of people or a combination of all these and more factors. That is another big question," said Holmes, whose work is funded by the National Institutes of Health.
What is certain, the Penn State researcher noted, is that multiple viruses arrive in New York state each season. In a connected world where emerging viruses can spread globally very quickly, Holmes says that the best way to protect communities is to have an extremely good system of disease surveillance in place and to develop universal vaccines that can protect against all kinds of influenza virus.
The balancing act: An enzyme that links endocytosis to membrane recycling
07.12.2016 | National Centre for Biological Sciences
Transforming plant cells from generalists to specialists
07.12.2016 | Duke University
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
07.12.2016 | Health and Medicine
07.12.2016 | Life Sciences
07.12.2016 | Health and Medicine