Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cell death in blood vessels may be an early target to prevent coronary disease

20.09.2007
EVGN scientist Martin Bennett, British Heart Foundation Professor of Cardiovascular Sciences at the Addenbrooke’s Hospital, Division of Cardiovascular Medicine in Cambridge (UK), identified the direct consequences of apoptosis of Vascular Smooth Muscle Cells (VSMC), the programmed cell death that occurs in atherosclerosis, which is a hallmark of vascular degeneration - leading as it often does to myocardial infarction.

In addition, the scientist highlighted the strong parallels existing between the apoptotic microenvironment in cardiovascular disease and those present in the tissues of a few degenerative diseases. In the long run, these data could provide better understanding of other untreatable human pathologies.

The sequence of reactions triggered by apoptosis was presented today, September 19th, at the Fourth Annual Meeting of the European Vascular Genomics Network (EVGN, www.evgn.org), the Network of excellence on cardiovascular disease, which is running in parallel with the 4th European Meeting on Vascular Biology and Medicine (EMVBM).

With more than 400 attendants from all over Europe and representatives from the rest of the world, among whom there are cardiologists, diabetes researchers, hematologists, thrombosis scientists, gene therapists and oncologists, the Bristol Meeting offers a stimulating environment for discussion and future planning.

... more about:
»Plaque »VSMC »apoptosis »atherosclerosis »prevent

Apoptosis, the programmed cell death that occurs when a cell has accumulated sufficient DNA damages that it is unable to repair its DNA, is centrally involved in the pathogenesis of a whole range of human illnesses and injury states, and atherosclerosis is no exception. However, until recently, its exact role in this pathology was unclear.

Martin Bennett, a leading cardiologist and atherosclerosis expert, set up a series of targeted experiments aimed at understanding the precise mechanism of action of this, otherwise useful, process.

“We decided – explained Bennett – to elucidate the role that VSMCs death has in the timeline of atherosclerosis progression. Using a mouse model that reproduces the human condition, we induced apoptosis of VSMCs only inside the vessel wall, observing, at first, a clear enlargement of the atherosclerotic plaques that almost doubled their size. This is a bad prognostic factor, as the more they grow the more the plaques become brittle”. That was exactly the second observation made: after the initial growth, the fibrous cap that encloses a typical plaque became thinner, whereas the plaque core increased. “All these signals – points out Bennett – could be useful at the bedside, for a real-time monitoring of atherosclerosis progression”. Not enough, after these first events, the researchers confirmed that the whole region involved in the apoptotic process undergoes calcification. This, in turn, prevents the remodelling of a vessel and, when occurs in a patient, it worsens his or her prognosis.

Furthermore, from Bennett’s investigation emerged striking analogies with two degenerative diseases: Marfan’s syndrome and Hutchinson Gilford Progeria. In both these diseases the tissues look much similar to the one analysed by Bennett in the atherosclerotic settings, with areas of calcifications, and the same kind of infiltrating cells.

“Early as they are, these data rise hope that apoptosis could be targeted at different levels, in order to prevent the cascade of reactions so noxious for the health. And that, possibly, it will help to find novel therapies also for other ailments”.

Francesca Noceti | alfa
Further information:
http://www.evgn.org/
http://www.ifom-ieo-campus.it

Further reports about: Plaque VSMC apoptosis atherosclerosis prevent

More articles from Life Sciences:

nachricht Cryo-electron microscopy achieves unprecedented resolution using new computational methods
24.03.2017 | DOE/Lawrence Berkeley National Laboratory

nachricht How cheetahs stay fit and healthy
24.03.2017 | Forschungsverbund Berlin e.V.

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

Argon is not the 'dope' for metallic hydrogen

24.03.2017 | Materials Sciences

Astronomers find unexpected, dust-obscured star formation in distant galaxy

24.03.2017 | Physics and Astronomy

Gravitational wave kicks monster black hole out of galactic core

24.03.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>