Genome sequence of stable Campylobacter strain deciphered
Scientists of the Institute of Food Research and their collaborators at the veterinary pharmaceutical company Intervet have deciphered and published the complete genome sequence of a strain of Campylobacter jejuni.
The food-poisoning bacterium C. jejuni is one of the major causes of gastroenteritis in humans, causing diarrhoea, stomach cramps and in rare cases a nervous condition called Guillain-Barré syndrome. Humans are commonly infected by eating undercooked poultry meat, which is contaminated during processing of the chickens. Surprisingly, the Campylobacter bacterium is commonly carried in the gut of birds without causing disease in the birds.
Like many bacteria, C. jejuni is able to avoid our body’s defences by altering the nature and content of its surface. These alterations are achieved by having regions of the bacterial chromosome that are able to make small random variations, resulting in different surface structures.
Genomic variability has been a problem for researchers investigating C. jejuni, since it potentially also causes differences between laboratories and even between experiments. In a project funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and Intervet, the Campylobacter group at IFR has determined and analysed the complete genome sequence of Campylobacter jejuni strain 81116 (also known as NCTC11828). This strain was selected because of its previously reported genomic stability over time.
The genome sequence reported by IFR and Intervet is 1,628,114 bases in length and notable for having fewer of the variable regions than the previously reported C. jejuni sequences. Strain 81116 is widely studied as it is amenable to genetic alterations, and grows well in poultry allowing this important natural reservoir to be studied. Thus the reported sequence will provide useful information for Campylobacter researchers worldwide, and is predicted to be a valuable resource for the research community.
Campylobacter research at IFR
Campylobacter research at IFR focuses on understanding the molecular processes involved in Campylobacter infections. State-of-the art techniques are used or developed for the analysis of virulence gene regulation and bacterial responses to stresses encountered during infection of avian and mammalian hosts or during survival in the environment. The aim is to provide an integrated, holistic approach to the investigation of Campylobacter biology and pathogenesis of infection, by combining both the study of Campylobacter physiology and genetics.
Zoe Dunford | alfa
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...