Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Genes and drugs team up to lower blood pressure

13.09.2007
Patients with high blood pressure respond very differently to antihypertensive medication, making treatment selection tricky for physicians. But new research published in the online open access journal, BMC Medical Genetics, pinpoints a number of gene-drug interactions that could allow medication to be tailored to individual patients based on their genetics.

Sharon Kardia from the University of Michigan together with a US team drawn from the University of Texas, Houston and the Mayo Clinic, Rochester, studied siblings with hypertension participating in a Genetic Epidemiology Network of Arteriopathy study. The team took blood pressure readings and details of the subjects' drug regimens. Using these data, the authors found a new set of single nucleotide polymorphisms (SNPs) on the adducin 2 (ADD2) gene that may influence the regulation of blood pressure among people with hypertension.

Variation in blood pressure was affected by genotype, drugs and interactions between the two. The researchers used cross-validation methods to test the predictive power of their findings on individuals outside the study group, eliminating false positive findings.

Three SNPs were associated with differential blood pressure responses in beta-blocker users versus diuretic users while two other SNPs were associated with differential responses in renin-angiotensin-aldosterone system (RAAS) inhibitor users versus diuretic users. The findings also provide initial evidence that the effects of genetic variation on blood pressure in people with untreated hypertension may be very different compared with those taking medication. Although the authors looked at individual SNPs, it is also likely that SNPs interact.

... more about:
»SNP »blood »blood pressure »hypertension »pressure

"We suspected that ADD2 could be associated with differences in response to different antihypertensives because adducins have been proposed to regulate renal tubular transport of Na+ reabsorption and the development of hypertension," says Kardia.

Today's drugs target the body's systems for regulating blood pressure, so understanding individuals' differing responses to hypertensive drugs based on genetic and environmental factors is particularly worthwhile to create tailored drug regimens. Prospective studies with individuals selected based on their genotype, along with further SNP investigations, are the next steps toward translating these findings into clinical practice.

Charlotte Webber | alfa
Further information:
http://www.biomedcentral.com/bmcmedgenet/

Further reports about: SNP blood blood pressure hypertension pressure

More articles from Life Sciences:

nachricht At last, butterflies get a bigger, better evolutionary tree
16.02.2018 | Florida Museum of Natural History

nachricht New treatment strategies for chronic kidney disease from the animal kingdom
16.02.2018 | Veterinärmedizinische Universität Wien

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

Im Focus: Autonomous 3D scanner supports individual manufacturing processes

Let’s say the armrest is broken in your vintage car. As things stand, you would need a lot of luck and persistence to find the right spare part. But in the world of Industrie 4.0 and production with batch sizes of one, you can simply scan the armrest and print it out. This is made possible by the first ever 3D scanner capable of working autonomously and in real time. The autonomous scanning system will be on display at the Hannover Messe Preview on February 6 and at the Hannover Messe proper from April 23 to 27, 2018 (Hall 6, Booth A30).

Part of the charm of vintage cars is that they stopped making them long ago, so it is special when you do see one out on the roads. If something breaks or...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Fingerprints of quantum entanglement

16.02.2018 | Information Technology

'Living bandages': NUST MISIS scientists develop biocompatible anti-burn nanofibers

16.02.2018 | Health and Medicine

Hubble sees Neptune's mysterious shrinking storm

16.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>