Based on computer vision and motion control, the automated microrobotic system is capable of immobilizing a large number of zebrafish embryos into a regular pattern within seconds and injecting 15 embryos (chorion unremoved) per minute with a success rate, survival rate, and phenotypic rate all close to 100%. The system and performance were reported in the journal PLoS ONE in an article entitled, “A Fully Automated Robotic System for Microinjection of Zebrafish Embryos.”
Zebrafish is a model organism widely used in life sciences. High-speed injection of zebrafish embryos is important for screening genes in genetics and drug molecules in drug discovery. The automated microrobotic system proves itself as a reliable tool for determining gene functions and more generally, for facilitating large-scale molecule screening.
The technology was licensed to Marksman Cellject Inc. (http://www.marksman-cellject.com) for commercialization. Marksman Cellject Inc. is a start-up biotechnology company created by The Innovations Group (TIG) (http://www.innovations.utoronto.ca).
Collaborating with the Toronto Centre for Advanced Reproductive Technology, a fertility clinic (http://www.tcartonline.com), Marksman Cellject Inc. has received an Ontario Centres of Excellence grant to extend the zebrafish injection technology to mouse/human oocyte/embryo injection for in-vitro fertilization applications.
TIG is part of the Office of Research at U of T with the mandate of commercializing discoveries developed by its researchers and healthcare partners in the areas of Physical Sciences, Information Technology and Life Science for society’s benefit. Among TIG’s other recent start-ups are Greencore Composites (http://www.greencorenfc.com), Cast Connex (http://www.castconnex.com), Opalux (http://www.opalux.com), and Sketch2 (press release - http://www.theglobeandmail.com/servlet/story/LAC.20070515.SRINNO15/TPStory/?query=innovation).
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26.05.2017 | Helmholtz-Zentrum für Infektionsforschung
Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
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An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
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Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
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An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
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