Neuronal conduction of excitation without action potentials based on ceramide production

This new mechanism involves molecules known to play a role in numerous mechanisms of cell functioning, but not hitherto in conduction of excitation.

To elucidate this mechanism, the teams have used a model of integrated physiology on an in vitro preparation in the mammal.

This study has been performed using neuropharmacological and biochemical techniques.

This study, reporting the first discovery of conduction of excitation without action potentials, opens up new perspectives for research by breaking away from the classic concept of neuronal functioning.

The neurons would thus be fitted with two modes of conduction of excitation, fast and slow, which might be used in different circumstances.

This would have important consequences in the fields of physiological research and clinical practice.