Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers develop long-lasting growth hormone

05.09.2007
Researchers at the University of Sheffield have developed a long-acting growth hormone for use in human therapy. The new discovery could mean that children and adults with growth hormone disorders will not have to have injections as often, reducing the need for daily treatments.

Most hormones and cytokines have a short life and therefore require frequent injections as therapy. However, the new technology developed by the multidisciplinary team at Sheffield, means that scientists and clinicians are able to generate effective, long-acting hormones which promote growth over a minimum of ten days, after just one injection.

The research, published in the prestigious journal Nature Medicine, shows that the hormones are able to act for longer because of unique characteristics in the new molecules created in Sheffield.

Hormones normally circulate in blood attached to binding proteins that prevent their clearance from the circulation and prolong their biological action. The new molecules created by the scientists, however, are able to bind to each other in a head-to-tail configuration, doubling their molecular mass in the bloodstream. This delays their absorption and elimination from the blood and therefore generates a hormone that will last for a longer period of time.

... more about:
»Injection »develop »hormone

Professor Richard Ross, from the University´s School of Medicine and Biomedical Sciences, said: "We are very excited by these results and believe this technology will bring significant benefit to patients. Children and adults with growth hormone deficiency have to give themselves daily injections and it is hoped that the new technology will reduce the number of times they have to do this to once every two weeks, or even once a month."

Professor Peter Artymiuk, a structural biologist in the University´s Department of Molecular Biology and Biotechnology, added: "Although we are only in the early stages of the drug development process, and any drugs resulting from this research are several years away from approval, it´s wonderful to see the science translate from the computer screen to what we hope will be real benefits for patients."

Professor Jon Sayers, from the University´s School of Medicine and Biomedical Sciences, commented: "We believe that the technology can also be applied to treat inflammatory diseases such as multiple-sclerosis, cancer and metabolic diseases."

The team of academics are founder shareholders in Asterion Ltd, a Biofusion portfolio company from the University of Sheffield, set up in 2001 to commercially exploit this breakthrough. The company, which has been supported by SUEL Ltd, the White Rose Seedcorn Fund and Biofusion, has a major research collaboration with the French pharmaceutical company Ipsen.

Lindsey Bird | EurekAlert!
Further information:
http://www.shef.ac.uk

Further reports about: Injection develop hormone

More articles from Life Sciences:

nachricht When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short
23.03.2017 | Institut für Pflanzenbiochemie

nachricht WPI team grows heart tissue on spinach leaves
23.03.2017 | Worcester Polytechnic Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

When Air is in Short Supply - Shedding light on plant stress reactions when oxygen runs short

23.03.2017 | Life Sciences

Researchers use light to remotely control curvature of plastics

23.03.2017 | Power and Electrical Engineering

Sea ice extent sinks to record lows at both poles

23.03.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>