Drs Joe Casey and Yves Sauvé found evidence for blindness associated with a gene involved in retinal pH regulation. Their characterization of a mouse model with a targeted disruption of the Slc4a3 gene has revealed a new cause of blindness.
Identification of Slc4a3 as underlying a previously unrecognized cause of blindness has direct clinical implications: it opens the door to a new diagnostic possibility for many yet unknown causes of blindness, including hereditary vitreoretinal degenerations (HVDs). No link has been established between Slc4a3 and HVDs.
The similarities between the disease of Slc4a3 deficient mice and individuals with HVDs, however, suggest that Slc4a3 null mice represent the first model of these blinding conditions, for which there is no cure.
Their findings thus lead to the conclusion that approaches targeting retinal extracellular pH regulation are worth exploring as treatments for HVDs and perhaps other types of blindness.Contact:
Andrew Hyde | alfa
Immune Defense Without Collateral Damage
23.01.2017 | Universität Basel
The interactome of infected neural cells reveals new therapeutic targets for Zika
23.01.2017 | D'Or Institute for Research and Education
For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.
According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
23.01.2017 | Health and Medicine
23.01.2017 | Physics and Astronomy
23.01.2017 | Process Engineering