Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


New viruses to treat bacterial diseases – "My enemies’ enemy is my friend”

Viruses found in the River Cam in Cambridge, famous as a haunt of students in their punts on long, lazy summer days, could become the next generation of antibiotics, according to scientists speaking today (Monday 3 September 2007) at the Society for General Microbiology’s 161st Meeting at the University of Edinburgh, UK, which runs from 3-6 September 2007.

With antibiotics now over-prescribed for treatments of bacterial infections, and patients failing to complete their courses of treatment properly, many bacteria are able to pick up an entire array of antibiotic resistance genes easily by swapping genetic material with each other.

MRSA – the multiple drug resistant strain of Staphylococcus aureus - and newly emerging strains of the superbug Clostridium difficile have forced medical researchers to realise that an entirely different approach is required to combat these bacteria.

“By using a virus that only attacks bacteria, called a phage – and some phages only attack specific types of bacteria – we can treat infections by targeting the exact strain of bacteria causing the disease”, says Ana Toribio from the Wellcome Trust Sanger Institute in Hinxton, Cambridgeshire, UK. “This is much more targeted than conventional antibiotic therapy”.

... more about:
»Treatment »antibiotic »bacterial »infections »phage »strain

The scientists used a close relative of Escherichia coli, the bacterium that commonly causes food poisoning and gastrointestinal infections in humans, called Citrobacter rodentium, which has exactly the same gastrointestinal effects in mice. They were able to treat the infected mice with a cocktail of phages obtained from the River Cam that target C. rodentium. At present they are optimizing the selection of the viruses by DNA analysis to utilise phage with different profiles.

“Using phages rather than traditional broad-spectrum antibiotics, which essentially try to kill all bacteria they come across, is much better because they do not upset the normal microbial balance in the body”, says Dr Derek Pickard from the Wellcome Trust Sanger Institute. “We all need good bacteria to help us fight off infections, to digest our food and provide us with essential nutrients, and conventional antibiotics can kill these too, while they are fighting the disease-causing bacteria”

Phage based treatment has been largely ignored until recently in Western Europe and the USA. The main human clinical reports have come from Eastern Europe, particularly the Tbilisi Bacteriophage Institute in Georgia where bacteriophages are used for successful treatment of infections such as diabetic ulcers and wounds. More studies are planned along western clinical trial lines with all the standards required.

“The more we can develop the treatment and understand the obstacles encountered in using this method to treat gut infections, the more likely we are to maximise its chance of success in the long term”, says Ana Toribio. “We have found that using a variety of phages to treat one disease has many benefits over just using one phage type to attack a dangerous strain of bacteria, overcoming any potential resistance to the phage from bacterial mutations”.

“This brings us back to the problem we are trying to address in the first place. If anything, conventional antibiotic treatment has led to MRSA and other superbug infections becoming not only more prevalent but also more infectious and dangerous. Bacteriophage therapy offers an alternative that needs to be taken seriously in Western Europe”, says Derek Pickard.

Lucy Goodchild | alfa
Further information:

Further reports about: Treatment antibiotic bacterial infections phage strain

More articles from Life Sciences:

nachricht Novel mechanisms of action discovered for the skin cancer medication Imiquimod
21.10.2016 | Technische Universität München

nachricht Second research flight into zero gravity
21.10.2016 | Universität Zürich

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

Im Focus: Ultra-thin ferroelectric material for next-generation electronics

'Ferroelectric' materials can switch between different states of electrical polarization in response to an external electric field. This flexibility means they show promise for many applications, for example in electronic devices and computer memory. Current ferroelectric materials are highly valued for their thermal and chemical stability and rapid electro-mechanical responses, but creating a material that is scalable down to the tiny sizes needed for technologies like silicon-based semiconductors (Si-based CMOS) has proven challenging.

Now, Hiroshi Funakubo and co-workers at the Tokyo Institute of Technology, in collaboration with researchers across Japan, have conducted experiments to...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Resolving the mystery of preeclampsia

21.10.2016 | Health and Medicine

Stanford researchers create new special-purpose computer that may someday save us billions

21.10.2016 | Information Technology

From ancient fossils to future cars

21.10.2016 | Materials Sciences

More VideoLinks >>>