Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Aluminium in breast tissue – a possible factor in the cause of breast cancer

29.08.2007
A new study has identified a regionally-specific distribution of aluminium in breast tissue which may have implications for the cause of breast cancer.

Scientists have found that the aluminium content of breast tissue and breast tissue fat was significantly higher in the outer regions of the breast, in close proximity to the area where there would be the highest density of antiperspirant.

Recent research has linked breast cancer with the use of aluminium-based, underarm antiperspirants. The known, but unaccounted for, higher incidence of tumours in the upper outer quadrant of the breast seemed to support such a contention. However, the identification of a mechanism of antiperspirant-induced breast cancer has remained elusive.

A team, led by Dr Chris Exley of the Birchall Centre for Inorganic Chemistry and Materials at Keele University in the UK, measured the aluminium content of breast tissue from 17 breast cancer patients recruited from Wythenshaw Hospital, Manchester, UK. Whether differences in the distribution of aluminium in the breast are related to the known higher incidence of tumours in the outer upper quadrant of the breast remains to be ascertained.

... more about:
»ALUMINIUM »Tissue »antiperspirant »cause »factor

The major constituent of antiperspirant is aluminium salts which have long been associated with cancer, as well as other human disease. The daily application of aluminium-based antiperspirants should result in the presence of aluminium in the tissue of the underarm and surrounding areas, though there is almost no data on aluminium in breast tissue.

Breast cancer is the most common malignancy in women and is the leading cause of death among women aged 35-54. The cause of breast cancer is unknown and is likely to be a combination of generic and environmental factors.

Each of the patients in the study had undergone a mastectomy and biopsies from four different regions of the breast on a transect from the outer (axilla and lateral) to the inner (middle and medial) breast were collected.

Tests showed that while there were significant differences in the concentrations of aluminium between individuals they did show “a statistically higher concentration of aluminium in the outer as compared with the inner region of the breast”.

The report, published in the Journal of Inorganic Biochemistry, goes on: “We have confirmed the presence of aluminium in breast tissue and its possible regional distribution within the breast. Higher content of aluminium in the outer breast might be explained by this region’s closer proximity to the underarm where the highest density of application of antiperspirant could be assumed. There is evidence that skin is permeable to aluminium when applied as antiperspirant.

“However, we have no direct evidence that the aluminium measured in these breast biopsies originated from antiperspirant. An alternative explanation might be that tumourous tissue acts as a ‘sink’ for systemic aluminium”.

But it goes on to say that “aluminium in breast tissue might contribute” to breast cancer.

“Aluminium is a metalloestrogen, it is genotoxic, is bound by DNA and has been shown to be carcinogenic. It is also a pro-oxidant and this unusual property might provide a mechanistic basis for any putative carcinogenicity. The confirmed presence of aluminium in breast tissue biopsies highlights its potential as a possible factor in the aetiology of breast cancer”.

Chris Stone | alfa
Further information:
http://www.keele.ac.uk

Further reports about: ALUMINIUM Tissue antiperspirant cause factor

More articles from Life Sciences:

nachricht Water world
20.11.2017 | Washington University in St. Louis

nachricht Carefully crafted light pulses control neuron activity
20.11.2017 | University of Illinois at Urbana-Champaign

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Antarctic landscape insights keep ice loss forecasts on the radar

20.11.2017 | Earth Sciences

Filling the gap: High-latitude volcanic eruptions also have global impact

20.11.2017 | Earth Sciences

Water world

20.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>