Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Conaway Lab Demonstrates Mechanism by which Transcription Factor Controls Gene Expression

28.08.2007
The Conaway Lab — led by Joan Conaway, Ph.D., and Ron Conaway, Ph.D., Investigators — has published findings that shed light on the role of the much-studied transcription factor YY1 in gene expression. Yong Cai, Ph.D., Research Specialist I, and Jingji Jin, Ph.D., Senior Research Associate, are the paper’s coequal first authors.

The paper, “YY1 functions with INO80 to activate transcription,” was posted to the Web site of Nature Structural & Molecular Biology on Aug. 26. It describes data showing that transcription factor YY1 works with a chromatin remodeling complex INO80.

“The paper offers the first demonstration of several interesting principles,” said Dr. Joan Conaway. “We learned that there is a role of the INO80 complex in gene regulation; that a chromatin remodeling complex plays a role as a coactivator for YY1; and that a transcription factor may travel with the remodeling complex required for it to gain access to promoters — suggesting that an initiating event in YY1-dependent gene activation is the corecruitment of YY1 and the human INO80 chromatin remodeling complex.”

YY1 is known to be important for turning “on” and “off” a significant number of genes, including genes that control cell division, cell differentiation, and development. Because of these contributions to cell cycle control, YY1 may eventually prove to be a good target for cancer therapy — but only if more can be learned about its functional mechanism.

“One of the most interesting findings in this paper is that one way YY1 controls gene expression is to bring the INO80 chromatin remodeling complex to the DNA sequences that control when a gene is turned on or off,” said Dr. Ron Conaway. “This process can make the gene available, or not, to the machinery that copies DNA into messenger RNA, which in turn directs the cell to make proteins.”

“This research is important because it illustrates that YY1 represents a switch point for modifying the activity of genes,” said Robb Krumlauf, Ph.D., Scientific Director. “We know that YY1 plays a significant role in regulating cellular processes, but this work from the Conaway Lab skillfully addresses questions about its mechanism of action, and provides a wealth of new information about an important transcription factor.”

Additional contributing authors from the Stowers Institute include Tingting Yao, Ph.D., Postdoctoral Research Fellow; Aaron Gottschalk, Predoctoral Researcher; Selene Swanson, Ph.D., Research Specialist II; Michael Washburn, Ph.D., Director of Proteomics; and Laurence Florens, Ph.D., Managing Director of Proteomics.

Contributing authors form the Department of Pathology at Harvard Medical School are Su Wu, Research Assistant Graduate Student; and Yang Shi, Ph.D., Professor of Pathology.

Drs. Conway hold faculty appointments in the Department of Biochemistry and Molecular Biology at the University of Kansas Medical Center. Dr. Joan Conaway was awarded the Helen Nelson Distinguished Chair by the Helen Nelson Medical Research Fund at the Greater Kansas City Community Foundation in 2005. More information about the Conaway Lab is available at www.stowers-institute.org/labs/ConawayLab.asp.

About the Stowers Institute
Housed in a 600,000 square-foot state-of-the-art facility on a 10-acre campus in the heart of Kansas City, Missouri, the Stowers Institute for Medical Research conducts basic research on fundamental processes of cellular life. Through its commitment to collaborative research and the use of cutting-edge technology, the Institute seeks more effective means of preventing and curing disease. The Institute was founded by Jim and Virginia Stowers, two cancer survivors who have created combined endowments of $2 billion in support of basic research of the highest quality.

Marie Jennings | EurekAlert!
Further information:
http://www.stowers-institute.org
http://www.stowers-institute.org/labs/ConawayLab.asp

Further reports about: Chromatin Conaway INO80 Stowers Institute YY1 remodeling specimen processing transcription

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>