The paper, “YY1 functions with INO80 to activate transcription,” was posted to the Web site of Nature Structural & Molecular Biology on Aug. 26. It describes data showing that transcription factor YY1 works with a chromatin remodeling complex INO80.
“The paper offers the first demonstration of several interesting principles,” said Dr. Joan Conaway. “We learned that there is a role of the INO80 complex in gene regulation; that a chromatin remodeling complex plays a role as a coactivator for YY1; and that a transcription factor may travel with the remodeling complex required for it to gain access to promoters — suggesting that an initiating event in YY1-dependent gene activation is the corecruitment of YY1 and the human INO80 chromatin remodeling complex.”
YY1 is known to be important for turning “on” and “off” a significant number of genes, including genes that control cell division, cell differentiation, and development. Because of these contributions to cell cycle control, YY1 may eventually prove to be a good target for cancer therapy — but only if more can be learned about its functional mechanism.
“One of the most interesting findings in this paper is that one way YY1 controls gene expression is to bring the INO80 chromatin remodeling complex to the DNA sequences that control when a gene is turned on or off,” said Dr. Ron Conaway. “This process can make the gene available, or not, to the machinery that copies DNA into messenger RNA, which in turn directs the cell to make proteins.”
“This research is important because it illustrates that YY1 represents a switch point for modifying the activity of genes,” said Robb Krumlauf, Ph.D., Scientific Director. “We know that YY1 plays a significant role in regulating cellular processes, but this work from the Conaway Lab skillfully addresses questions about its mechanism of action, and provides a wealth of new information about an important transcription factor.”
Additional contributing authors from the Stowers Institute include Tingting Yao, Ph.D., Postdoctoral Research Fellow; Aaron Gottschalk, Predoctoral Researcher; Selene Swanson, Ph.D., Research Specialist II; Michael Washburn, Ph.D., Director of Proteomics; and Laurence Florens, Ph.D., Managing Director of Proteomics.
Contributing authors form the Department of Pathology at Harvard Medical School are Su Wu, Research Assistant Graduate Student; and Yang Shi, Ph.D., Professor of Pathology.
Drs. Conway hold faculty appointments in the Department of Biochemistry and Molecular Biology at the University of Kansas Medical Center. Dr. Joan Conaway was awarded the Helen Nelson Distinguished Chair by the Helen Nelson Medical Research Fund at the Greater Kansas City Community Foundation in 2005. More information about the Conaway Lab is available at www.stowers-institute.org/labs/ConawayLab.asp.About the Stowers Institute
Marie Jennings | EurekAlert!
Multi-institutional collaboration uncovers how molecular machines assemble
02.12.2016 | Salk Institute
Fertilized egg cells trigger and monitor loss of sperm’s epigenetic memory
02.12.2016 | IMBA - Institut für Molekulare Biotechnologie der Österreichischen Akademie der Wissenschaften GmbH
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water
In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...
The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.
Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
02.12.2016 | Medical Engineering
02.12.2016 | Agricultural and Forestry Science
02.12.2016 | Physics and Astronomy