Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Formation of new pancreatic blood vessels can determine malignancy

07.08.2007
Scientists of the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) have shown how the formation of new blood vessels (angiogenesis) is regulated by a network of hundreds of genes. The transition from healthy pancreatic tissue to pancreatic cancer is characterized by increased activity of angiogenesis-promoting genes.

Microscopically small, newly formed tumors may rest in dormant state for months or even years without forming their own blood vessels. It takes a kind of cellular switch to activate genes that are required for the sprouting of new blood vessels. New vessel formation is often accompanied by rapid, invasive tumor growth and metastasis. Drugs directed against key molecules of angiogenesis are already successfully used today to prolong survival of many cancer patients.

Dr. Dr. Amir Abdollahi and Professor Dr. Dr. Peter Huber at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ), collaborating with Heidelberg University and US researchers, have investigated what happens at the molecular level when the angiogenetic switch is operated. The investigators studied the genetic response of blood vessel cells (endothelial cells) to known angiogenesis-promoting factors as well as angiogenesis inhibitors. In the “proangiogenetic” state, angiogenesis-promoting genes are switched on, while antiangiogenetic genes are switched off. The organism responds by sprouting new blood vessels. When the gene network is in “antiangiogenetic” state, the reverse is the case, i.e. the formation of blood vessels is prevented.

Measurements of gene activity in tissues samples of patients with diseases of the pancreas have shown the clinical relevance of these findings. From normal pancreatic tissue via chronic pancreatitis through to pancreatic cancer the researchers found a steady increase in the activity of those genes that had been identified in the cell experiment as angiogenesis-promoting. This trend was studied in more detail on a gene called PPARd, whose role in tumor development and angiogenesis had not been known before. The scientists were able to show that the level of PPARd protein steadily increases from normal tissue via pancreatitis tissue through to metastasizing pancreatic cancer. Other tumors, such as breast cancer and prostate cancer, were also found to produce increased levels of the angiogenesis-promoting protein.

In order to study the protein’s actual role in tumor vessel formation, the investigators transplanted skin and lung cancer cells into genetically engineered mice that do not produce their own PPARd. Compared to normal animals, tumor growth in the genetically engineered mice was signifantly slower with poorer supply of vessels.

However, PPARd is only one of many key switches within the angiogenetic network. “Regulation of angiogenesis seems to be more complex than previously assumed,“ says project leader Peter Huber. “Therefore we think that in cancer treatment it is not sufficient to inhibit only one of the participants. Antiangiogenetic therapy might be improved by targeting several of the network’s key switches. One of these could be PPARd.”

The task of the Deutsches Krebsforschungszentrum in Heidelberg (German Cancer Research Center, DKFZ) is to systematically investigate the mechanisms of cancer development and to identify cancer risk factors. The results of this basic research are expected to lead to new approaches in the prevention, diagnosis and treatment of cancer. The Center is financed to 90 percent by the Federal Ministry of Education and Research and to 10 percent by the State of Baden-Wuerttemberg. It is a member of the Helmholtz Association of National Research Centers (Helmholtz-Gemeinschaft Deutscher Forschungszentren e.V.).

Press Officer | alfa
Further information:
http://www.dkfz.de

Further reports about: Angiogenesis PPARd angiogenesis-promoting blood vessel pancreatic vessel

More articles from Life Sciences:

nachricht New catalyst controls activation of a carbon-hydrogen bond
21.11.2017 | Emory Health Sciences

nachricht The main switch
21.11.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Previous evidence of water on mars now identified as grainflows

21.11.2017 | Physics and Astronomy

NASA's James Webb Space Telescope completes final cryogenic testing

21.11.2017 | Physics and Astronomy

New catalyst controls activation of a carbon-hydrogen bond

21.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>