Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists move closer to bio-engineered bladders

01.08.2007
Researchers at the University of York are using an understanding of the special cells that line the bladder to develop ways of restoring continence to patients with serious bladder conditions, including cancer.

The research, highlighted in the quarterly magazine of the Biotechnology and Biological Sciences Research Council (BBSRC) this week, is looking at urothelial cells. These are the specialised lining cells of the bladder that enable it to retain urine. The cells have a very low turnover rate, but scientists have found that if the bladder is damaged, the urothelial cells are able to rapidly re-grow to repair the wound. The researchers hope to harness this property to engineer new bladders.

The York researchers have developed a series of models that mean they can study human urothelial cells in the laboratory. Of these models, the most important is their development of a urothelial cell sheet that functions as it would in the bladder. When the researchers create a wound in this model, the cells regenerate to repair the damage - just as they would in the body.

Pharmaceutical companies should soon be able to use the research models to test therapies for the bladder, but the longer term aim for this research is to help patients who have lost bladder function or have had all or part of their bladder removed because of cancer.

... more about:
»Bladder »urothelial

Research leader, Professor Jenny Southgate, explains: "The models we have developed mean that we have been able to examine how urothelial cells in the bladder self-renew to cope with injury.

"With this basic understanding of how the cells work, we are moving towards being able to engineer new bladders. Currently, substitute bladders can be created by using a section of the patient's bowel, but this can lead to complications, as the bowel does not have the same urine-holding properties as urothelial cells. One solution could be to use laboratory-grown urothelial cells to line a section of bowel."

The hope in the long term is that collaborative research to combine Professor Southgate's work with biomaterial studies at the Universities of Durham and Leeds could mean engineered bladder tissue ready for transplantation.

Professor Southgate, who is Director of the Jack Birch Unit for Molecular Carcinogenesis, in the Department of Biology at the University of York said: "Our most exciting work moving forward is to develop natural and synthetic biomaterials that could be combined with regenerating urothelial cells. This has the potential to produce viable bladder tissue for transplant into patients who need replacement bladders."

The York research highlights the importance of basic biology research in underpinning medical advances. Professor Nigel Brown, BBSRC Director of Science and Technology, commented: "Fundamental bioscience research forms the foundation for much of the medical advances we have today and hope for in the future. We need a solid understanding of how our bodies work and maintain themselves before we can understand what goes wrong when they become diseased and how the disease can be treated."

Michelle Kilfoyle | alfa
Further information:
http://www.bbsrc.ac.uk

Further reports about: Bladder urothelial

More articles from Life Sciences:

nachricht Could this protein protect people against coronary artery disease?
17.11.2017 | University of North Carolina Health Care

nachricht Microbial resident enables beetles to feed on a leafy diet
17.11.2017 | Max-Planck-Institut für chemische Ökologie

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>