The US military is funding a three-year study to evaluate the effectiveness of the enzyme, known as GOT, in protecting animals against the damaging cognitive and coordination problems resulting from exposure to the organophosphorus nerve agent.
The study will be carried out by Israeli firm Braintact, and follows earlier unpublished work with rats which showed the enzyme successfully protected the animals against neurological problems caused by exposure to paraoxon, a model compound for nerve agents such as sarin, soman and VX.
GOT’s ability to protect against neurological damage, the company claims, is down to the fact it can bind to, and chemically inactivate, a chemical called glutamate, also found in the blood and brain. In normal, healthy individuals, glutamate’s role is as a neurotransmitter carrying nerve impulses between cells. When cells are damaged or dying, however, as on exposure to nerve agents – or as a result of other forms of brain injury including stroke or disease – they release far more glutamate than normal, over-exciting and killing nearby nerve cells.
In related work published earlier this year, by Vivian Teichberg at the Weizmann Institute of Science and researchers at the Beer Sheva University in Israel, activation of GOT in the blood was found to prevent much of the brain damage caused after brain injury in rats. ‘It appears that most of the damage that is caused is due to excess glutamate since we can entirely prevent the brain cell death after traumatic injury,’ Teichberg said.
SCI Press Office | alfa
Symbiotic bacteria: from hitchhiker to beetle bodyguard
28.04.2017 | Johannes Gutenberg-Universität Mainz
Nose2Brain – Better Therapy for Multiple Sclerosis
28.04.2017 | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
28.04.2017 | Event News
20.04.2017 | Event News
18.04.2017 | Event News
28.04.2017 | Medical Engineering
28.04.2017 | Earth Sciences
28.04.2017 | Life Sciences