Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Toxic milk

24.07.2007
Scientists find key protein affecting quality of maternal-infant nutrition

In the August 1 issue of G&D, Dr. Ronald Evans (Salk Institute) and colleagues report on their discovery that mutations in the mouse gene encoding PPARã adversely affect lactation milk quality, and have serious health consequences for nursing pups.

“By examining PPARã functions in vivo, our work reveals an unexpected link between diet, inflammation and the quality of mothers milk, “ explained Dr. Evans.

PPARã (peroxisome proliferator-activator receptor gamma) is a nuclear receptor that is known to regulate metabolism and inflammation in various organisms. In fact, human PPARã is the main target of the drug class of thiazolidinediones (TZDs), which is used to manage diabetes.

... more about:
»Evans »PPARã »Quality

Dr. Evans and colleagues sought to determine the role of PPARã in the lactating mammary gland. They generated a strain of mice that, as adults, lacked PPARã only in hematopoietic and endothelial cells. When these PPARã-deficient animals became mothers, they appeared normal, but the milk they produced most certainly was not.

"We were delighted and surprised by the discovery because it directly explores one of life's most common events - breast feeding. These findings will enhance the understanding of why milk is healthful and the molecular pathways that create the bodies own quality control pipe line," says Dr. Evans.

The researchers noticed that pups of the PPARã-deficient females – who were, themselves, genetically normal - were displaying a number of abnormalities, most noticeably marked hair loss across their trunks and growth retardation. The scientists determined that these abnormalities were due to their ingestion of “toxic milk” from their PPARã-deficient mothers: Either fostering by PPARã-normal mothers or weaning to solid food effectively cured these small and balding pups.

Through a variety of experimental approaches, Dr. Evans and colleagues determined that PPARã loss results in increased levels of pro-inflammatory lipids being released into the mothers’ milk. Ingestion of this “toxic milk” sets off an inflammatory response in the skin of nursing pups, which ultimately disrupts the hair growth cycle and renders them largely bald. In fact, treatment with the common anti-inflammatory aspirin completely rescues hair loss in these pups.

Heather Cosel | EurekAlert!
Further information:
http://www.cshl.edu

Further reports about: Evans PPARã Quality

More articles from Life Sciences:

nachricht Warming ponds could accelerate climate change
21.02.2017 | University of Exeter

nachricht An alternative to opioids? Compound from marine snail is potent pain reliever
21.02.2017 | University of Utah

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Impacts of mass coral die-off on Indian Ocean reefs revealed

21.02.2017 | Earth Sciences

Novel breast tomosynthesis technique reduces screening recall rate

21.02.2017 | Medical Engineering

Use your Voice – and Smart Homes will “LISTEN”

21.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>