The UAB heads a European research project on proteases and pathological processes
A research group of the UAB Institute of Biotechnology and Biomedicine and the UAB Department of Biochemistry and Molecular Biology, directed by Francesc Xavier Avilés, is the coordinator of a European project aimed at studying proteases with fluorescent molecules that allow their monitoring in healthy and pathological situations.
Entitled "Chemical Genomics by Activity Monitoring of Proteases" (CAMP), the project was designed with the final objective of developing drugs to control proteases in inflammations, cardiovascular diseases, cancer and neurodegeneration.
The project has already begun and is being carried out by a consortium of research groups from different universities, small and medium sized enterprises, and a large pharmaceutical company. Although under UAB coordination, six other collaborating centres from Germany, Switzerland, Slovenia, United Kingdom and Denmark also work on the project. CAMP forms part of the European Union's Specific Targeted Catering Projects (STREP) and has a duration of three years.
Proteases are enzymes, or proteins that act as catalysts for other proteins when regulating many of the biological processes involved in blood coagulation, food processing, extracellular matrix renewing, etc. Without the regulation of protease activity, numerous pathologies can appear, such as cardiovascular, neuron and autoimmune diseases, inflammations, osteoporosis, arthritis and cancer.
The main objective of the CAMP project is to obtain information on the structure, activity and evolution of the proteases and its inhibitors (molecules that alter their functions) by monitoring their activities in situ and in vivo.
This will then help discover where the proteases that the drugs need to act on can be found. With this aim, the researchers have developed substrates with fluorescent molecules that will be attached to the proteases. This will allow them to monitor the proteases in tissue culture and live animals. The information obtained will then enable scientists to develop specific protease inhibitors.
Octavi López Coronado | alfa
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...