Because of their similarity to patient tumors, these models are an exceptional tool for testing the efficacy of new drugs, adapting treatments to tumor characteristics, unraveling resistance to certain treatments, and as a result limiting the need for clinical trials in patients. Institut Curie and Inserm medical oncologists, surgeons, pathologists and biologists collaborated on this work on mouse models which can now be extended to other types of cancers. The 25 breast tumor models are described in a study published in the 1 July 2007 issue of Clinical Cancer Research.
To help clinicians in their search for more effective treatments, Marie-France Poupon and her team in Institut Curie Inserm Unit 612 “Genotoxicology, signaling and experimental radiotherapy” have developed the largest ever series of human breasts cancers grafted into mice. This six-year study would not have been successful without close collaboration between Institut Curie and Inserm medical oncologists, surgeons, pathologists, and biologists.
These breast cancer xenografts in mice reproduce the genetic, genomic, and histological characteristics of the patient-derived tumor tissues. So they recapitulate features of the original tumors, such as overexpression of HER2 receptors, absence or presence of estrogen receptors, mutation of P53, and react identically to chemotherapy.
Twenty-five models of breast tumors in mice of different biological profiles have been established. These models are an excellent preclinical research tool and can be used to test the efficacy of new drugs and novel therapeutic combinations, as well as analyze the response to treatment and adapt it to the tumor characteristics. This will help in the design of clinical trials and hasten the development of new treatments.
This work is continuing within the framework of the creation of a Preclinical Investigation Laboratory in the Translational Research Department at the Institut Curie, with a view to extending this series of tumor models to other types of cancers, such as pediatric cancers, melanoma, lung cancer, ovarian cancer, and cancers of the bronchi, prostate, and colon.
Breast cancer is the most frequent cancer in women and affects one in ten women in the developed world. Every year in France there are 42 000 new cases. Between 1980 and 2000, the number of cases increased by almost 60%, largely as a result of increasingly efficient detection and because people are living longer. Breast cancer is most commonly detected in women aged between 50 and 69 years of age (half of all cases), but can occur at any age, albeit very rarely before the age of 25.
Mortality has declined because of earlier detection and improved treatments combining surgery, radiotherapy, and chemotherapy, depending on the tumor characteristics. When the diagnosis is made early enough, conservative surgery is possible: the tumor is removed and the breast conserved. When the tumor is larger, or is accompanied by extensive precancerous lesions, it is sometimes essential to remove the breast (mastectomy).
CWRU researchers find a chemical solution to shrink digital data storage
22.06.2017 | Case Western Reserve University
Warming temperatures threaten sea turtles
22.06.2017 | Swansea University
Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.
Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...
Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.
As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...
Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.
With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...
Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine
Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...
Germany counts high-precision manufacturing processes among its advantages as a location. It’s not just the aerospace and automotive industries that require almost waste-free, high-precision manufacturing to provide an efficient way of testing the shape and orientation tolerances of products. Since current inline measurement technology not yet provides the required accuracy, the Fraunhofer Institute for Laser Technology ILT is collaborating with four renowned industry partners in the INSPIRE project to develop inline sensors with a new accuracy class. Funded by the German Federal Ministry of Education and Research (BMBF), the project is scheduled to run until the end of 2019.
New Manufacturing Technologies for New Products
19.06.2017 | Event News
13.06.2017 | Event News
13.06.2017 | Event News
22.06.2017 | Medical Engineering
22.06.2017 | Life Sciences
22.06.2017 | Life Sciences