Because living organisms contain millions of different molecules, identifying or separating any single one of these from their natural environment in order to carry out research work or perform diagnoses is quite like looking for a needle in a haystack. A number of molecular separation technologies are of course available, and are used by laboratories on a daily basis, but they are often unwieldy and costly. Scientists the world over are therefore attempting to develop a new generation of analytic devices, known as labs-on-a-chip, where all the technological phases of laboratory work are integrated into speedy automated procedures, in what can be deemed to be a single sample to diagnosis step.
CNRS scientists (1) working at the Institut Curie, together with an ESPCI team, have broken new ground in this field, coming closer to such systems with a technology they have called Ephesia (2) . Combining knowledge and tools developed in physics, chemistry, and biology, they have developed an original approach based on the use of self-organizing nanospheres, which handle the key molecule sorting phase within these chips. This new technology paves the way to a whole field of applications both in genetics and in biochemistry, ranging from the study of molecules to medical diagnostics, in particular in oncology with a view to detecting mutations or micrometastases. These new results are to be published by Science magazine on March 22.
A wide range of labs-on-a-chip using very different concepts and materials are currently being developed the world over. The basic idea which they all share is that the various component phases involved in the analysis of given samples are conducted within microchannels (ranging from one tenth to one hundredth of a millimeter) etched onto a microchip. The samples and the substances used to process them, with a view to extracting specific molecules, are injected into these channels and moved about using micropumps, ultra-small pneumatic systems, and electric fields. The device developed by the Institut Curie team is based on a silicone rubber wafer with a 4 cm diameter, within which fine channels have been moulded. This medium was initially developed by G.M. Whitesides at Harvard University in the United States and is well suited for mass production because of its low cost. One of the major issues in developing a lab-on-a-chip involves building molecule-sorting sieves that will operate within these microchannels. This is the problem to which the Institut Curie and ESPCI teams have provided an original solution, interfacing physics, chemistry, and biology.
Catherine Goupillon | alphagalileo
North and South Cooperation to Combat Tuberculosis
22.03.2018 | Universität Zürich
Researchers Discover New Anti-Cancer Protein
22.03.2018 | Universität Basel
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
22.03.2018 | Life Sciences
22.03.2018 | Life Sciences
22.03.2018 | Earth Sciences