Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Allergy Molecule Identified

02.07.2007
A vital molecule for resistance to food allergy has been identified and offers a potential target for therapy.

There is currently no way to treat food allergy and the only way for sufferers to manage the problem is to avoid certain foods and make sure they have injectable adrenaline at hand.


The intimate interplay between two cell types of the immune system, dendritic cells (larger cells) and and T cells (white smaller surrounding cells) that play a central role in orchestrating finely balanced immune responses.

Scientists led by Dr Claudio Nicoletti at the Institute of Food Research in Norwich have found that a molecule called Interleukin-12 (IL-12) is absent during allergic responses. Dr Nicoletti suggests that by delivering an allergen in the presence of IL-12, allergic reactions could be brought back under control.

“A food protein can be perfectly harmless to one person and lethal to another, said Dr Nicoletti. “We have identified the missing molecule that normally keeps immune responses under control and appropriate.”

... more about:
»Allergy »Nicoletti »immune

Having a food allergy means that the immune system responds to a food protein as if it was harmful. The immune system produces immunoglobulin E (IgE) antibodies, which normally help the body fight parasites. In the most severe cases individuals can suffer life-threatening reactions, including anaphylactic shock.

In previous research, Dr Nicoletti found that special types of white blood cells called dendritic cells are important in helping the immune system decide on how to respond to foreign molecules. In the latest research, Dr Nicoletti compared the activity of dendritic cells in the gut and in the spleen of allergic and allergy resistant mice. He found that in the gut of susceptible mice, dendritic cells have stopped producing IL-12.

This research was carried out in collaboration with the University of Siena.

“We have identified a molecule that is very important for the regulation of immune response and for the first time clearly represents a potential target for the therapy of allergy. This is currently under investigation”, said Dr Nicoletti.

David Reading, director of the Anaphylaxis Campaign, said: “Food allergy can place an extremely heavy burden on the families affected. We welcome this research and look forward to further developments.”

Zoe Dunford | alfa
Further information:
http://www.ifr.ac.uk/

Further reports about: Allergy Nicoletti immune

More articles from Life Sciences:

nachricht Scientists unlock ability to generate new sensory hair cells
22.02.2017 | Brigham and Women's Hospital

nachricht New insights into the information processing of motor neurons
22.02.2017 | Max Planck Florida Institute for Neuroscience

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Microhotplates for a smart gas sensor

22.02.2017 | Power and Electrical Engineering

Scientists unlock ability to generate new sensory hair cells

22.02.2017 | Life Sciences

Prediction: More gas-giants will be found orbiting Sun-like stars

22.02.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>