Though much research is focused on developing drugs and vaccines targeted to the bacterium that causes tularemia, Francisella tularensis, little is known about the role that antibodies play in protecting against infection.
A research team led by Dennis W. Metzger, Ph.D., at the Albany Medical College in New York has now shown that treating laboratory mice with a serum containing tularemia-specific antibodies protects the mice against F. tularensis, not only if given before exposure to lethal doses of inhalational F. tularensis but also up to 48 hours after exposure. These findings suggest a possible alternative treatment approach to traditional antibiotics.
In the absence of a licensed vaccine, such an approach might prove especially useful early on in the case of an intentional act of bioterrorism. The tularemia-specific antibodies may enhance an individual’s immune responses to the bacteria after exposure, in essence acting as a surrogate vaccine.
Other advantages of this approach over conventional methods of treatment include the fact that it is rapid and specific; it could be used in people with weakened immune systems; and it minimizes the chances of contributing to treatment-resistant bacteria.
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19.02.2018 | California Institute of Technology
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19.02.2018 | Biophysical Society
For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.
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Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.
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Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters
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