Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Nitric Oxide - Concomitant Of Metastases

26.06.2007
The cancerous growth excrescence and formation of its metastases in the cerebrum are preceded by increased level of nitric oxide derivatives in oncological patients’ blood plasma. Specialists of the biochemistry laboratory of the Rostov Oncology Research Institute, who conducted the investigation, believe that the nitric oxide derivatives content in blood plasma may be of prognostic value.

The cerebral metastases occur approximately with 25 to 30 percent of oncological patients. At that, they appear independent of the primary tumor location. Metastatic disease is accompanied by the basic tumor growth, and in this case the patient is ususally doomed. Half of the patients with cerebral metastases die of them, in spite of conducted treatment. Therefore, metastases in the cerebrum should be discovered as early as possible and their development should be suppressed. Nitric oxide is convenient to be used as a diagnostic marker.

Nitric oxide and its derivatives play a significant role in cancer occurrence and development. Nitric oxide influences the vessel growth in the tumor, the grow of tumors per se, metastatic disease and the apoptosis process (programmed cell death). Its level depends on treatment efficiency.

Experiments involved 24 patients of the neuro-oncology division of the Rostov Oncology Research Institute. Among them, there were patients with malignant growths of the mammary gland, lung, kidney, thyroid gland and with melanoma. The reference group was made of 15 persons without oncological diseases. The contents of nitric oxide derivatives – peroxinitrite, nitrosohaemoglobin, nitrosoglutathione, nitrotyrosine – in blood plasma was determined for all the patients. The analysis was performed via the spectrophotometric method.

... more about:
»Derivatives »Oxide »Plasma »metastases »nitric

It has turned out that the patients with multiple metastases in the brain had much higher contents of nitric oxide derivatives in blood plasma than the patients with solitary metastases and healthy people did. As for the patients with solitary metastases, they were classified into two sub-groups. Five patients had the peroxinitrite and nitrosohaemoglobin level much higher than the average values in this group, respective indices of other patients not differing from the reference level. Over time, metastases in the brain started to develop rapidly with two persons from the subgroup with high contents of nitric oxide derivatives, with one patient – metastases appeared in lymph nodes, and the primary tumor increase in size with two other patients.

As the nitoderivative leve increases before clinicians can record the primary tumor or cerebral metastases growth, the Rostov oncologists suggest that this index should be used for the disease prognosis.

Nadezda Markina | alfa
Further information:
http://www.informnauka.ru

Further reports about: Derivatives Oxide Plasma metastases nitric

More articles from Life Sciences:

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

nachricht Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>