Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mathematics reveals genetic pattern of tumor growth

25.06.2007
Finding could serve as basis for future cancer treatments

Using mathematical theory, UC Irvine scientists have shed light on one of cancer’s most troubling puzzles – how cancer cells can alter their own genetic makeup to accelerate tumor growth. The discovery shows for the first time why this change occurs, providing insight into how cancerous tumors thrive and a potential foundation for future cancer treatments.

UCI mathematicians Natalia Komarova, Alexander Sadovsky and Frederic Wan looked at cancer from the point of view of a tumor and asked: What can a tumor do to optimize its own growth? They focused on the phenomenon of genetic instability, a common feature of cancer in which cells mutate at an abnormally fast rate. These mutations can cause cancer cells to grow, or they can cause the cells to die.

The scientists found that cancerous tumors grow best when they are very unstable in early stages of development and become stable in later stages. In other words, tumors thrive when cancerous cells mutate to speed up malignant transformation, and then stay that way by turning off the mutation rate.

... more about:
»Genetic »Komarova »Mutation »UCI »instability »pattern

The study appeared this week in the Royal Society journal Interface.

“Mathematical theory can help us understand cancer,” said Komarova, associate professor of mathematics at UCI. “If we know what cancer is doing, we might be able to find ways to fight it.”

Previous studies have observed this genetic pattern by using laboratory techniques, but the UCI research is the first to explain why the pattern leads to tumor growth. The occurrence of genetic instability is often debated by cancer scientists, some of whom believe that cancer feeds on this instability and others who believe it is a side-effect of the cancer itself.

To determine the pattern of genetic changes that leads to the most robust tumor growth, Komarova and her colleagues used a mathematical technique called optimal control theory in which they considered a tumor with set characteristics, then changed the cell mutation variable to see under which circumstances the tumor grew best.

“The mutation rate serves as the control knob. Then, we can calculate mathematically how long it takes a tumor with given parameters to reach a certain size,” Komarova said. “We found that at early stages of tumor growth, instability is advantageous, and later on it becomes an impediment. This explains why many tumors exhibit a high level of instability at first, and become stable later in their development.”

This research was supported by a Sloan Fellowship and grants from the National Institutes of Health.

About the University of California, Irvine: The University of California, Irvine is a top-ranked university dedicated to research, scholarship and community service. Founded in 1965, UCI is among the fastest-growing University of California campuses, with more than 25,000 undergraduate and graduate students and about 1,800 faculty members. The second-largest employer in dynamic Orange County, UCI contributes an annual economic impact of $3.7 billion. For more UCI news, visit www.today.uci.edu.

News Radio: UCI maintains on campus an ISDN line for conducting interviews with its faculty and experts. The use of this line is available free-of-charge to radio news programs/stations who wish to interview UCI faculty and experts. Use of the ISDN line is subject to availability and approval by the university.

Jennifer Fitzenberger | EurekAlert!
Further information:
http://www.uci.edu

Further reports about: Genetic Komarova Mutation UCI instability pattern

More articles from Life Sciences:

nachricht Tag it EASI – a new method for accurate protein analysis
20.06.2018 | Max-Planck-Institut für Biochemie

nachricht How to track and trace a protein: Nanosensors monitor intracellular deliveries
19.06.2018 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Creating a new composite fuel for new-generation fast reactors

20.06.2018 | Materials Sciences

Game-changing finding pushes 3D-printing to the molecular limit

20.06.2018 | Materials Sciences

Could this material enable autonomous vehicles to come to market sooner?

20.06.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>