What is the role of inflammation in cancer? Which molecular and cell mechanisms promote inflammation? How do antiinflammatory agents work and which molecules do we need to target for antiinflammatories to be more effective? These are essential questions for scientists studying the mechanisms that activate and control innate immune response. Fifteen top international specialists in this field will gather from 25-27 June for a conference entitled, “Inflammation and Chronic Disease”, part of the “Barcelona BioMed” conference series organised by the Institute for Research in Biomedicine (IRB Barcelona) and the Fundación BBVA. The event will be hosted by the Institut d’Estudis Catalans (IEC).
Inflammation and Chronic Disease
Inflammation is the innate response of the immune system that occurs when an organism sustains a lesion or infection. When the damaged tissue heals, the inflammation disappears, but when the inflammation remains active and becomes chronic, it can severely damage the affected tissue.
Asthma, rheumatoid arthritis, inflammatory bowel disease, psoriasis, multiple sclerosis, Alzheimer’s disease and, most recently, type 2 diabetes and cancer, are diseases that have been associated with chronic inflammation. Carme Caelles, researcher at IRB Barcelona and co-organiser of the conference, explains that “until recently inflammation has been considered simply a side effect of cancer. In the last three years, however, growing evidence has pointed to the active role of inflammation not just at the beginning but also in the promotion and progression of the disease”.
Inflammation is also linked to obesity and type 2 diabetes. The presence of excessive fat activates the production of cytokines, proteins involved in inflammatory processes that end up promoting insulin resistance. There are currently several drugs in clinical testing that inhibit cytokines as a treatment for diabetes. “Not all anti-inflammatory drugs work for all diseases. The challenge is to identify and understand complete mechanisms so that the most effective drugs can be designed for each disease, with the fewest side effects possible”, points out Caelles.
The conference will host a full range of specialists and will cover a variety of areas. Speakers will present their research into the basic mechanisms that activate inflammation, as well as the results from other studies directly associated with the disease. Michael Karin, co-organiser of the event and researcher at the University of California San Diego (USA), for example, published with his team a conclusive study linking inflammation, infection and cancer in Nature earlier this year. Another internationally renowned scientist is Gabriel Nuñez, from the University of Michigan Medical School (USA), whose laboratory has been studying the “autoinflammatory syndrome”. Jorge Moscat, from Genome Research Institute (USA), is a leading expert in signal transduction processes during the inflammatory response. Antonio Celada, an immunologist at IRB Barcelona, will present the latest results of his team on macrophages, cells that play a key role in the body’s immune response.
Could this protein protect people against coronary artery disease?
17.11.2017 | University of North Carolina Health Care
Microbial resident enables beetles to feed on a leafy diet
17.11.2017 | Max-Planck-Institut für chemische Ökologie
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
17.11.2017 | Physics and Astronomy
17.11.2017 | Health and Medicine
17.11.2017 | Studies and Analyses