What is the role of inflammation in cancer? Which molecular and cell mechanisms promote inflammation? How do antiinflammatory agents work and which molecules do we need to target for antiinflammatories to be more effective? These are essential questions for scientists studying the mechanisms that activate and control innate immune response. Fifteen top international specialists in this field will gather from 25-27 June for a conference entitled, “Inflammation and Chronic Disease”, part of the “Barcelona BioMed” conference series organised by the Institute for Research in Biomedicine (IRB Barcelona) and the Fundación BBVA. The event will be hosted by the Institut d’Estudis Catalans (IEC).
Inflammation and Chronic Disease
Inflammation is the innate response of the immune system that occurs when an organism sustains a lesion or infection. When the damaged tissue heals, the inflammation disappears, but when the inflammation remains active and becomes chronic, it can severely damage the affected tissue.
Asthma, rheumatoid arthritis, inflammatory bowel disease, psoriasis, multiple sclerosis, Alzheimer’s disease and, most recently, type 2 diabetes and cancer, are diseases that have been associated with chronic inflammation. Carme Caelles, researcher at IRB Barcelona and co-organiser of the conference, explains that “until recently inflammation has been considered simply a side effect of cancer. In the last three years, however, growing evidence has pointed to the active role of inflammation not just at the beginning but also in the promotion and progression of the disease”.
Inflammation is also linked to obesity and type 2 diabetes. The presence of excessive fat activates the production of cytokines, proteins involved in inflammatory processes that end up promoting insulin resistance. There are currently several drugs in clinical testing that inhibit cytokines as a treatment for diabetes. “Not all anti-inflammatory drugs work for all diseases. The challenge is to identify and understand complete mechanisms so that the most effective drugs can be designed for each disease, with the fewest side effects possible”, points out Caelles.
The conference will host a full range of specialists and will cover a variety of areas. Speakers will present their research into the basic mechanisms that activate inflammation, as well as the results from other studies directly associated with the disease. Michael Karin, co-organiser of the event and researcher at the University of California San Diego (USA), for example, published with his team a conclusive study linking inflammation, infection and cancer in Nature earlier this year. Another internationally renowned scientist is Gabriel Nuñez, from the University of Michigan Medical School (USA), whose laboratory has been studying the “autoinflammatory syndrome”. Jorge Moscat, from Genome Research Institute (USA), is a leading expert in signal transduction processes during the inflammatory response. Antonio Celada, an immunologist at IRB Barcelona, will present the latest results of his team on macrophages, cells that play a key role in the body’s immune response.
Oestrogen regulates pathological changes of bones via bone lining cells
28.07.2017 | Veterinärmedizinische Universität Wien
Programming cells with computer-like logic
27.07.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard
Spectrally narrow x-ray pulses may be “sharpened” by purely mechanical means. This sounds surprisingly, but a team of theoretical and experimental physicists developed and realized such a method. It is based on fast motions, precisely synchronized with the pulses, of a target interacting with the x-ray light. Thereby, photons are redistributed within the x-ray pulse to the desired spectral region.
A team of theoretical physicists from the MPI for Nuclear Physics (MPIK) in Heidelberg has developed a novel method to intensify the spectrally broad x-ray...
Physicists working with researcher Oriol Romero-Isart devised a new simple scheme to theoretically generate arbitrarily short and focused electromagnetic fields. This new tool could be used for precise sensing and in microscopy.
Microwaves, heat radiation, light and X-radiation are examples for electromagnetic waves. Many applications require to focus the electromagnetic fields to...
Strong light-matter coupling in these semiconducting tubes may hold the key to electrically pumped lasers
Light-matter quasi-particles can be generated electrically in semiconducting carbon nanotubes. Material scientists and physicists from Heidelberg University...
Fraunhofer IPA has developed a proximity sensor made from silicone and carbon nanotubes (CNT) which detects objects and determines their position. The materials and printing process used mean that the sensor is extremely flexible, economical and can be used for large surfaces. Industry and research partners can use and further develop this innovation straight away.
At first glance, the proximity sensor appears to be nothing special: a thin, elastic layer of silicone onto which black square surfaces are printed, but these...
3-D shape acquisition using water displacement as the shape sensor for the reconstruction of complex objects
A global team of computer scientists and engineers have developed an innovative technique that more completely reconstructs challenging 3D objects. An ancient...
26.07.2017 | Event News
21.07.2017 | Event News
19.07.2017 | Event News
28.07.2017 | Health and Medicine
28.07.2017 | Power and Electrical Engineering
28.07.2017 | Life Sciences