Scientists at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital (Canada), the European Molecular Biology Laboratory (Germany), and Massachusetts Institute of Technology (USA) have created a new computational method called NetworKIN. This method uses biological networks to better identify relationships between molecules. In a cover story featured in the 14 June 2007 edition of the journal Cell, the scientists report insights into the regulation of protein networks that will ultimately help to target human disease.
“Thousands of proteins can be changed (via phosphorylation) but until now, it has not been possible to know which protein has made the change,” states Dr. Tony Pawson, distinguished investigator at the Lunenfeld.
Proteins are the functional agents that carry out all processes in a cell. But they only rarely act alone. Instead they accomplish their effects as part of big networks. How proteins interact in these networks often depends on phosphorylation, the addition of a phosphate at specific sites on a protein. Kinases are proteins that bring about the phosphorylation of other proteins and in this way regulate all cellular processes.
“Our method works a bit like getting a recommendation from Amazon,” says Dr. Peer Bork, group leader at EMBL. “The fact that certain books have been bought by the same customers tells you that they have something in common. In the same way biological networks tell us about shared features between different proteins. These help us predicting which kinases are likely to act on them.”
“By getting a network-wide view, multiple aberrant genes of kinase-controlled processes are more easily targeted,” states Dr. Rune Linding, postdoctoral fellow, Samuel Lunenfeld Research Institute. “In the future, the treatment of complex human diseases will be treated by targeting multiple genes.” Complex diseases like cancer often contain defects in several processes controlled by kinases.
Published in the current issue of Cell.
View http://www.embl.org/aboutus/news/press/2007/15jun07/ and download image.Anna-Lynn Wegener
Anna-Lynn Wegener | EMBL
Flavins keep a handy helper in their pocket
25.04.2018 | University of Freiburg
Complete skin regeneration system of fish unraveled
24.04.2018 | Tokyo Institute of Technology
At the Hannover Messe 2018, the Bundesanstalt für Materialforschung und-prüfung (BAM) will show how, in the future, astronauts could produce their own tools or spare parts in zero gravity using 3D printing. This will reduce, weight and transport costs for space missions. Visitors can experience the innovative additive manufacturing process live at the fair.
Powder-based additive manufacturing in zero gravity is the name of the project in which a component is produced by applying metallic powder layers and then...
Physicists at the Laboratory for Attosecond Physics, which is jointly run by Ludwig-Maximilians-Universität and the Max Planck Institute of Quantum Optics, have developed a high-power laser system that generates ultrashort pulses of light covering a large share of the mid-infrared spectrum. The researchers envisage a wide range of applications for the technology – in the early diagnosis of cancer, for instance.
Molecules are the building blocks of life. Like all other organisms, we are made of them. They control our biorhythm, and they can also reflect our state of...
University of Connecticut researchers have created a biodegradable composite made of silk fibers that can be used to repair broken load-bearing bones without the complications sometimes presented by other materials.
Repairing major load-bearing bones such as those in the leg can be a long and uncomfortable process.
Study published in the journal ACS Applied Materials & Interfaces is the outcome of an international effort that included teams from Dresden and Berlin in Germany, and the US.
Scientists at the Helmholtz-Zentrum Dresden-Rossendorf (HZDR) together with colleagues from the Helmholtz-Zentrum Berlin (HZB) and the University of Virginia...
Novel highly efficient and brilliant gamma-ray source: Based on model calculations, physicists of the Max PIanck Institute for Nuclear Physics in Heidelberg propose a novel method for an efficient high-brilliance gamma-ray source. A giant collimated gamma-ray pulse is generated from the interaction of a dense ultra-relativistic electron beam with a thin solid conductor. Energetic gamma-rays are copiously produced as the electron beam splits into filaments while propagating across the conductor. The resulting gamma-ray energy and flux enable novel experiments in nuclear and fundamental physics.
The typical wavelength of light interacting with an object of the microcosm scales with the size of this object. For atoms, this ranges from visible light to...
13.04.2018 | Event News
12.04.2018 | Event News
09.04.2018 | Event News
25.04.2018 | Physics and Astronomy
25.04.2018 | Physics and Astronomy
25.04.2018 | Information Technology