Using a combination of mouse mutant analyses, organ culture experiments, and gene expression studies, Xiu-Ping Wang and colleagues identify the key signaling molecules that regulate epithelial stem cell proliferation in the stem cell niche. Their work is published online this week in the open-access journal PLoS Biology.
The researchers show that signals from the adjacent mesenchymal tissue regulate epithelial stem cells and form a complex regulatory network with epithelial signals. They also show that spatial differences in the expression levels of two key genes, Activin and Follistatin, contribute to the characteristic asymmetry of rodent incisors, which are covered by enamel only on their labial (front) side. Subtle variations in this or related regulatory networks may explain the different regenerative capacities and asymmetric development of various organs and animal species.
Citation: Wang XP, Suomalainen M, Felszeghy S, Zelarayan LC, Alonso MT, et al. (2007) An integrated gene regulatory network controls stem cell proliferation in teeth. PLoS Biol 5(6): e159. doi:10.1371/journal.pbio.0050159.
Natalie Bouaravong | EurekAlert!
Antimicrobial substances identified in Komodo dragon blood
23.02.2017 | American Chemical Society
New Mechanisms of Gene Inactivation may prevent Aging and Cancer
23.02.2017 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
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The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
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Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
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