Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Identification of genetic risk factor for coeliac disease promises improved treatment

12.06.2007
An international research consortium investigating the genetic causes of intestinal inflammatory conditions has identified a new genetic risk factor for coeliac disease. The findings, published online today (10 June 2007) in the science journal Nature Genetics, could pave the way towards improved diagnostics and treatments for the common, lifelong complaint.

Led by David van Heel, Professor of Gastrointestinal Genetics at Queen Mary, University of London, the study - funded by the charity Coeliac UK, and the Wellcome Trust - has revealed that those suffering from coeliac disease lack a protective DNA sequence in a specific gene region, otherwise found in healthy individuals.

Behind the success of the study are the Human Genome Project and the Hap Map Project, international research efforts to reveal the entire sequence of all the human chromosomes - and the functional units embedded within - and to correlate that information to common sequence variation in the human population.

Dr Panos Deloukas, Senior Investigator in Human Genetics at the Wellcome Trust Sanger Institute, and part of the research consortium, said: “These resources coupled with technological advances have enabled us to scan variation across the human genome in large numbers of people for association to disease.” The Sanger Institute made available to the study the genome data on 1500 British individuals used as controls (i.e without coeliac disease). The consortium studied over four thousand individuals with and without coeliac disease, amongst British, Irish and Dutch populations.

... more about:
»Genetic »Risk »coeliac »coeliac disease »risk factor

What they found is that healthy individuals more often have a protective DNA sequence in the interleukin-2 and interleukin-21 gene region than individuals with coeliac disease. Interleukin-2 and interleukin-21 are cytokine proteins secreted by white blood cells that control inflammation. It is likely that the protective DNA sequence leads to different amounts of these cytokines being produced – than in someone with coeliac disease – providing defence against intestinal inflammation.

Coeliac disease is found in around 1 in 100 of the British population. It is caused by intolerance to gluten - a protein found in wheat, barley and rye - which results in damage to the gut, preventing normal digestion and absorption of food. If undetected it can lead to, amongst other things, anaemia, poor bone health, and weight loss. Although the majority of people are diagnosed in mid-life, symptoms can present themselves at anytime, for example during illness, stress, or post-trauma. There is a strong inherited (genetic) risk.

Professor David van Heel, chief investigator in the study, said; “We previously knew that coeliac individuals had a specific tissue type which recognised wheat proteins. We did not know why healthy individuals who had the same tissue type did not develop symptoms or disease. The first findings from our study suggest that interleukin genes that control inflammation are critical. We expect to find more disease risk factors from further in-depth analysis of the genome wide data.”

Sarah Sleet, Chief Executive of Coeliac UK said: ‘This research heralds an important breakthrough in understanding better who is likely to develop coeliac disease. Around 1 in 100 people develop the disease but predicting who is susceptible is like searching for a needle in a haystack. Currently genetic testing is a blunt instrument which can only narrow down the search to around one third of the general population’.

The study provides a road-map to enable discovery of further genetic risk factors predisposing to coeliac disease.

Alex Fernandes | EurekAlert!
Further information:
http://www.qmul.ac.uk
http://www.sanger.ac.uk

Further reports about: Genetic Risk coeliac coeliac disease risk factor

More articles from Life Sciences:

nachricht New risk factors for anxiety disorders
24.02.2017 | Julius-Maximilians-Universität Würzburg

nachricht Stingless bees have their nests protected by soldiers
24.02.2017 | Johannes Gutenberg-Universität Mainz

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>