Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

The unexpected connection of two gene regulation mechanisms points to new ways for the fight against leukemia

12.06.2007
When the activity of individual genes it is longer required, there are two main mechanisms responsible for the “switching off”, mainly DNA methylation and the Polycomb protein complex.

Sometimes, these mechanisms lose their efficiency and some of the genes that should be “switched off” remain active. This, in turn, could lead to uncontrolled cellular proliferation, and tumorigenesis. These mechanisms, present both in lower organisms as well as in mammals, have always been thought to be separated and independent.

The work, which appears on the cover this week in the June issue of the prestigious journal Cancer Cell, carried out by researchers of the Differentiation and Cancer Programme, at the Centre for Genomic Regulation (CRG), in Barcelona (Spain), demonstrates the cross-talk between these two gene silencing mechanisms in patients suffering from acute leukemia. The work, led by the ICREA researcher Luciano Di Croce, head of the group Epigenetics and Cancer, at the CRG, performed in collaboration with Kristian Helin’s group, at the Biotech Research and Innovation Centre in Copenhagen (Denmark), and Dr. Nomdedeu’s group, at the Santa Creu and Sant Pau Hospital, in Barcelona, will have important consequences in the development of new anti-tumor therapies. On the one hand, the study shows a better understanding of the basic mechanisms of gene regulation and, on the other hand, identifies a possible new pathway to reactivate erroneously “switched off” genes in tumors. In 2002, in a study published in Science, Di Croce showed that uncontrolled DNA methylation contributed to tumor progression in its first stages. Less than a year ago, Di Croce’s group described, in another study published in Nature, the biochemical connection between the Polycomb protein complex and the enzymes methylating the DNA (DNA methyltransferases).

In this new study, Di Croce has shown that the two mechanisms are not only interconnected in leukemic cells, but also that one reinforces the other and, more importantly, that one needs the other. Therefore - and this is one of the most interesting aspects of the investigation - if one of these mechanisms is blocked by specific drugs, the other will also be affected. The results achieved will allow, in the future, identifying new chemical compounds able to block both mechanisms simultaneously and exclusively, without altering other cellular mechanisms. For these reasons, this is one of the new investigations lines recently adopted by the group led by Di Croce.

Gloria Lligadas | alfa
Further information:
http://www.crg.es

Further reports about: Croce connection leukemia off”

More articles from Life Sciences:

nachricht Water world
20.11.2017 | Washington University in St. Louis

nachricht Carefully crafted light pulses control neuron activity
20.11.2017 | University of Illinois at Urbana-Champaign

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Water world

20.11.2017 | Life Sciences

Less is more to produce top-notch 2D materials

20.11.2017 | Materials Sciences

Carefully crafted light pulses control neuron activity

20.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>