Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Breakthrough for treatment of fatal heart condition

06.06.2007
Researchers at the University of Leeds have found a mechanism to prevent a potentially fatal heart condition that can strike without warning.

Dr Lezanne Ooi, a postdoctoral researcher in the Faculty of Biological Sciences, has found that the progression of cardiac hypertrophy can be halted by increasing one of the body’s naturally occurring proteins. “This is a significant discovery because whilst the symptoms can be managed, the cause of heart hypertrophy cannot yet be treated. This research provides a first step in the search for a possible treatment.” says Dr Ooi.

Cardiac hypertrophy is a relatively common condition often caused by high blood pressure, or can be the result of a genetic predisposition, resulting in an abnormal thickening of the heart muscle. It is known to affect 1 in 500 people in the UK and US and can lead to heart failure, arrhythmias and sudden death. The condition varies in its manifestation, with some people suffering severe symptoms – such as breathlessness, fatigue and chest pain - and others being entirely asymptomatic. In those not displaying any symptoms, death can be its first presentation, therefore the scale of the problem is not fully known. It is also the most common cause of sudden cardiac death in athletes, as hypertrophic hearts are unable to cope with intense physical activity.

Dr Ooi’s study is the first to identify the mechanism behind specific changes in protein levels that impact upon cardiac cell size. Levels of two proteins, known as ANP and BNP, are naturally higher in foetal hearts and the hearts of babies and children, but should drop as an individual matures. However, in adults with cardiac hypertrophy these levels increase to become abnormally high .

... more about:
»Condition »Ooi »cardiac »hypertrophy »symptoms

Dr Ooi has found that an increase in a third protein in the body, known as REST, can halt the rise of the proteins causing cardiac hypertrophy, which, for the first time, offers an approach to treating the cause of heart hypertrophy rather than its symptoms.

“The challenge is now to find a therapy that controls the source of the problem on an ongoing basis. If a way can now be found to translate this research into a therapeutic application, our findings will have an enormous impact on individuals suffering from the condition”, says Dr Ooi.

Dr Ooi’s work on cardiac hypertrophy has recently been recognised at the Experimental Biology conference in Washington DC in May. She was presented with the postdoctoral award from the American Association of Anatomists for her work, which was funded by the British Heart Foundation .

Clare Elsley | alfa
Further information:
http://www.leeds.ac.uk
http://www.leeds.ac.uk/media/index.htm

Further reports about: Condition Ooi cardiac hypertrophy symptoms

More articles from Life Sciences:

nachricht A novel socio-ecological approach helps identifying suitable wolf habitats
17.02.2017 | Universität Zürich

nachricht New, ultra-flexible probes form reliable, scar-free integration with the brain
16.02.2017 | University of Texas at Austin

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Biocompatible 3-D tracking system has potential to improve robot-assisted surgery

17.02.2017 | Medical Engineering

Real-time MRI analysis powered by supercomputers

17.02.2017 | Medical Engineering

Antibiotic effective against drug-resistant bacteria in pediatric skin infections

17.02.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>