Dr Lezanne Ooi, a postdoctoral researcher in the Faculty of Biological Sciences, has found that the progression of cardiac hypertrophy can be halted by increasing one of the body’s naturally occurring proteins. “This is a significant discovery because whilst the symptoms can be managed, the cause of heart hypertrophy cannot yet be treated. This research provides a first step in the search for a possible treatment.” says Dr Ooi.
Cardiac hypertrophy is a relatively common condition often caused by high blood pressure, or can be the result of a genetic predisposition, resulting in an abnormal thickening of the heart muscle. It is known to affect 1 in 500 people in the UK and US and can lead to heart failure, arrhythmias and sudden death. The condition varies in its manifestation, with some people suffering severe symptoms – such as breathlessness, fatigue and chest pain - and others being entirely asymptomatic. In those not displaying any symptoms, death can be its first presentation, therefore the scale of the problem is not fully known. It is also the most common cause of sudden cardiac death in athletes, as hypertrophic hearts are unable to cope with intense physical activity.
Dr Ooi’s study is the first to identify the mechanism behind specific changes in protein levels that impact upon cardiac cell size. Levels of two proteins, known as ANP and BNP, are naturally higher in foetal hearts and the hearts of babies and children, but should drop as an individual matures. However, in adults with cardiac hypertrophy these levels increase to become abnormally high .
Dr Ooi has found that an increase in a third protein in the body, known as REST, can halt the rise of the proteins causing cardiac hypertrophy, which, for the first time, offers an approach to treating the cause of heart hypertrophy rather than its symptoms.
“The challenge is now to find a therapy that controls the source of the problem on an ongoing basis. If a way can now be found to translate this research into a therapeutic application, our findings will have an enormous impact on individuals suffering from the condition”, says Dr Ooi.
Dr Ooi’s work on cardiac hypertrophy has recently been recognised at the Experimental Biology conference in Washington DC in May. She was presented with the postdoctoral award from the American Association of Anatomists for her work, which was funded by the British Heart Foundation .
Meadows beat out shrubs when it comes to storing carbon
23.11.2017 | Norwegian University of Science and Technology
Migrating Cells: Folds in the cell membrane supply material for necessary blebs
23.11.2017 | Westfälische Wilhelms-Universität Münster
Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
23.11.2017 | Information Technology
23.11.2017 | Physics and Astronomy
23.11.2017 | Life Sciences