Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Systems Characterization of Cell Surface Receptors

04.06.2007
Cells communicate with their environment through molecules on their surface known as receptors. Receptors bind ligands - specific companion molecules that either carry information about the outside environment or are critical cell nutrients. A variety of receptors are internalized into the cell through a process known as endocytosis. Receptors display a wide range of state-dependent endocytosis rates, but the functional significance of these patterns is not well understood.

In a paper publishing today (June 1) in the Open Access journal PLoS Computational Biology, Drs. Shankaran, Resat and Wiley from the Pacific Northwest National Laboratory employ a generalized mathematical model to comparatively explore the design principles of signal transduction and transport receptors.

The authors use a new module-based systems theory approach along with quantitative metrics for network function and robustness to show that endocytosis and other receptor/ligand properties can be described by just a few control parameters. Using mathematical analysis, the authors show that the efficiency and robustness of receptor systems are encoded by two fundamental parameters: the avidity which quantifies the ability of a receptor system to capture ligand, and the consumption which quantifies the ability to internalize bound ligand.

By examining a number of receptor systems, the authors demonstrate that the response of receptor systems can be characterized as being: i) avidity-controlled, which depends primarily on ligand capture efficiency, ii) consumption-controlled where the ability to internalize surface-bound ligand is the primary control parameter, and iii) dual-sensitive, in which both the avidity and consumption parameters are important. The location of various receptor systems in control parameter space dictates their specific function and regulation.

... more about:
»Ligand »Receptors »endocytosis »receptor

Most significantly, the authors argue that the evolution of a given receptor system can be understood in terms of its optimal location in avidity-consumption parameter space. For example, induced endocytosis can be shown to be an optimal solution for achieving high fidelity information transmission for signaling receptors. Overall, this study develops and applies a new strategy for quantifying the phenotype of complex systems that should be generally applicable to a wide range of problems in systems biology research.

The research was funded by the National Institutes of Health and the Biomolecular Systems Initiative at PNNL.

Andrew Hyde | alfa
Further information:
http://www.plos.org
http://compbiol.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pcbi.0030101

Further reports about: Ligand Receptors endocytosis receptor

More articles from Life Sciences:

nachricht Making fuel out of thick air
08.12.2017 | DOE/Argonne National Laboratory

nachricht ‘Spying’ on the hidden geometry of complex networks through machine intelligence
08.12.2017 | Technische Universität Dresden

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

Im Focus: Virtual Reality for Bacteria

An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications

Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...

Im Focus: A space-time sensor for light-matter interactions

Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.

The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Midwife and signpost for photons

11.12.2017 | Physics and Astronomy

How do megacities impact coastal seas? Searching for evidence in Chinese marginal seas

11.12.2017 | Earth Sciences

PhoxTroT: Optical Interconnect Technologies Revolutionized Data Centers and HPC Systems

11.12.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>