In a paper publishing today (June 1) in the Open Access journal PLoS Computational Biology, Drs. Shankaran, Resat and Wiley from the Pacific Northwest National Laboratory employ a generalized mathematical model to comparatively explore the design principles of signal transduction and transport receptors.
The authors use a new module-based systems theory approach along with quantitative metrics for network function and robustness to show that endocytosis and other receptor/ligand properties can be described by just a few control parameters. Using mathematical analysis, the authors show that the efficiency and robustness of receptor systems are encoded by two fundamental parameters: the avidity which quantifies the ability of a receptor system to capture ligand, and the consumption which quantifies the ability to internalize bound ligand.
By examining a number of receptor systems, the authors demonstrate that the response of receptor systems can be characterized as being: i) avidity-controlled, which depends primarily on ligand capture efficiency, ii) consumption-controlled where the ability to internalize surface-bound ligand is the primary control parameter, and iii) dual-sensitive, in which both the avidity and consumption parameters are important. The location of various receptor systems in control parameter space dictates their specific function and regulation.
Most significantly, the authors argue that the evolution of a given receptor system can be understood in terms of its optimal location in avidity-consumption parameter space. For example, induced endocytosis can be shown to be an optimal solution for achieving high fidelity information transmission for signaling receptors. Overall, this study develops and applies a new strategy for quantifying the phenotype of complex systems that should be generally applicable to a wide range of problems in systems biology research.
The research was funded by the National Institutes of Health and the Biomolecular Systems Initiative at PNNL.
Andrew Hyde | alfa
Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Chemists at FAU successfully demonstrate imine hydrogenation with inexpensive main group metal
22.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
18.05.2018 | Power and Electrical Engineering
18.05.2018 | Information Technology
18.05.2018 | Information Technology