Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Scientists develop new drugs to fight colon and breast cancer more effectively

04.06.2007
The doctoral thesis 'Potencial terapéutico de nuevos fármacos antitumorales. Estudio sobre líneas celulares epiteliales' (Therapeutic Potential of New Antitumor Drugs.

A Study on Epithelial Cell Lines) has allowed for the development of six new drugs to fight colon and breast cancer more effectively than other currently used drugs. The study was conducted at the Department of Human Anatomy and Embryology at the University of Granada (Universidad de Granada [http://www.ugr.es]) by Octavio Caba Pérez, member of the research group "Avances en Biomedicina" (Progress in Biomedicine), under the direction of professors Antonia Aránega, Juan Antonio Marchal and Fernando Rodríguez.

The importance of this study, in which researchers from the Department of Pharmaceutical and Organic Chemistry have also collaborated, is that it enabled the identification of a total of six antitumor compounds similar to 5-fluorouracil (5-FU), one of the most widely-used drugs nowadays to fight colon and breast cancer. These compounds are more effective against malignant cells (those which are cancerous) and less toxic against benign cells (those which are unnecessarily destroyed or harmed with treatments such as chemotherapy).

As Caba Pérez points out, the current method used to fight tumors “produces several 'collateral damages'. A drug can be very effective against breast cancer, but it can also affect the rest of the benign epithelial tissue. As everybody knows, current treatments for cancer destroy a large number of unaffected cells in addition to affected cells,” says Caba Pérez.

... more about:
»Caba »Perez »colon

In this study researchers analyzed more than 150 drugs aimed at reducing the toxicity of the 5-FU against the benign cells, thus avoiding the reproduction of new carcinomas or other side effects. “We discarded compounds until we finally found six which have shown to be better than currently used drugs,” says Caba Pérez.

Research on cell lines

So far, the study has been conducted on cell lines, and not on patients, using a new technique called “Microarrays” or “DNA Chips”, which enables the identification of the effects produced by drugs on each gene — the lowest and most specific level that Medicine can deal with.

“Our research,” says Caba Pérez, “has been conducted with absolute precision with the aim of obtaining the lowest possible concentration of drug producing the most significant effect on cancerous cells”. Therefore, this study has shown the importance of the presence of some toxic compounds like chlorine, flourine or uracil in drugs. This presence is one of the variables used to develop new antitumor drugs.

Part of the results of this study (which has been possible thanks to cooperation between the UGR [http://www.ugr.es] and the company VILPOMAS) have been published in the January 1 issue of the international journal "Tetrahedron". The remainder of the results will be published in various international journals on Biomedicine.

Antonio Marín Ruiz | alfa
Further information:
http://prensa.ugr.es/prensa/research/index.php

Further reports about: Caba Perez colon

More articles from Life Sciences:

nachricht Symbiotic bacteria: from hitchhiker to beetle bodyguard
28.04.2017 | Johannes Gutenberg-Universität Mainz

nachricht Nose2Brain – Better Therapy for Multiple Sclerosis
28.04.2017 | Fraunhofer-Institut für Grenzflächen- und Bioverfahrenstechnik IGB

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>