Scientists from Institute of Biophysics and Nanosystems Research (IBN), Austrian Academy of Sciences and of Centre for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, USA report the study of “Tuning Curvature and Stability of Monoolein Bilayers by Designer Lipid-Like Peptide Surfactants” in the May 30th issue of the online, open-access journal PLoS ONE. Their findings not only help us to understand the basic science of how lipid-like peptides interact with lipid molecules, but also may provide new strategies for the encapsulation and the delivery of biological active materials. They detailed their findings in the report on the impact of integrating short surfactant-like designer peptides in lipidic nanostructures.
Anan Yaghmur, Michael Rappolt, Peter Laggner and Shuguang Zhang reported the formations of dynamic nanostructures of lipid-like peptides that are like two-headed Janus, both water-loving and water-hating, which represent a new class of designer materials using common amino acids, the same basic molecules from meat, beans and fruits. These lipid-like peptides have excellent potential to solubilize membrane proteins and enzymes, and - as now demonstrated - can also be utilized to stabilize different self-assembled liquid crystalline nanostructures. Moreover, the surface charge density of lipidic nanostructures can be varied in a simple manner.
Dr. Anan Yaghmur, first author of the study, comments on the study, “the addition of small amounts of designer lipid-like peptides is sufficient to form systems with excellent potential for various biotechnological applications such as the encapsulation of water-insoluble drugs and the delivery of biological active materials.”
Currently, many anticancer drugs are difficult to deliver to patients due to their difficulty to be soluble in water. “This is a systematic study to combine with lipid molecules,” Shuguang Zhang of MIT, a co-author said, “people have been curious about if these similar molecules can interact. This study provided the first answer”. “Since these lipid-like peptides can be designed, just like to design an elegant watch, an art object, a music instrument, a ski, or a pair of sunglasses, we have the ultimate control to the outcome of the structure and their properties” Zhang added.
This study stemmed from a scientific visit by Peter Laggner to Shuguang Zhang at MIT in Cambridge, USA in May 2006. They shared some ideas and decided to collaborate since Laggner is a world-expert on nanostructure using small angle X-ray scattering and Zhang can provide the designer lipid-like peptides that he has been studied since 2000.
In the near future, many colloidal aqueous dispersions, which are similar to milk and some paints, with confined inner nanostructures, will offer unique characteristics like high drug load capacities and low viscosity. Here these designer lipid-like peptides may play a key role in improving effective drug delivery systems.
Individual Receptors Caught at Work
19.10.2017 | Julius-Maximilians-Universität Würzburg
Rapid environmental change makes species more vulnerable to extinction
19.10.2017 | Universität Zürich
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
17.10.2017 | Event News
10.10.2017 | Event News
10.10.2017 | Event News
19.10.2017 | Materials Sciences
19.10.2017 | Materials Sciences
19.10.2017 | Physics and Astronomy