Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Caspase-14 protects our skin against UVB and dehydration

22.05.2007
Ultraviolet rays can be harmful to our skin and pave the way to the onset of skin cancers.

VIB researchers connected to Ghent University have demonstrated that the caspase-14 protein - whose function has been unknown up to now - not only plays a role in maintaining the balance of moisture in the skin but also offers protection against UVB rays. Future strategies that increase the production of caspase-14 will open new possibilities for fortifying the skin as a barrier against all kinds of stress.

Sunbathing and the pernicious consequences for our skin

Sunlight is needed for the development of our bodies and minds. Still, we should not expose ourselves to it too often. The UV index provides an indication of the true intensity of the sun’s rays and the risks that go along with them.

... more about:
»Epidermis »Protect »UVB »caspase-14

UV rays cause functional alterations in the most important components of our skin: the keratinocytes. In addition to causing normal sunburn and suppressing our immune responses, UVB damages the DNA in our cells, which can lead to cancer. In the last 15 years, the number of new cases of melanoma (the most dangerous skin cancer in Belgium) has practically doubled to 1500 cases per year.

Caspase-14

Caspases are proteins that are involved in inflammation reactions and in programmed cell death or apoptosis. Apoptosis is important in all stages of life. During embryonal development, for example, apoptosis ensures that undesirable or outmoded tissues disappear. In the mid-1990s, Peter Vandenabeele and his colleagues were able to isolate 9 caspase family members in mice. The properties and substrates of a number of caspases are already known. However, caspase-14 is a maverick in that it is found very specifically in the skin and is activated during the last stage of skin cell maturation. Due to the action of caspase-14, the outer epidermis of our skin contains dead cells that are released as flakes of skin.

Mice as model

To investigate the function of caspase-14, Geertrui Denecker and colleagues, under the direction of Wim Declercq and Peter Vandenabeele, developed knock-out mice that could no longer produce the protein. The shiny and lichenified skin of mice without caspase-14 is a sign that the composition of the skin’s epidermis has been altered. The lack of caspase-14 causes defects in the processing of a protein that plays a major role in maintaining the skin’s structure and balance of moisture, which can explain the skin’s dehydration.

But one of our skin’s most important functions is to protect us against UVB radiation. The researchers in Ghent have found that the filtering action of the epidermis of mice without caspase-14 decreases dramatically.

The skin as barrier

The absence of caspase-14 has very harmful effects on the skin’s protective barrier function, which results in loss of water and diminished protection against UVB. This research sheds light on a portion of the mechanisms that operate in the skin’s epidermis. The identification of molecules involved in caspase-14 dependent processes could well be important to the pharmaceutical industry, which is always seeking agents that prevent sunburn and ageing of the skin.

Ann Van Gysel | alfa
Further information:
http://www.vib.be

Further reports about: Epidermis Protect UVB caspase-14

More articles from Life Sciences:

nachricht Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>