A challenging goal in biology is to understand how the principal cellular functions are integrated so that cells achieve viability and optimal fitness under a wide range of nutritional conditions. Scientists from the French research centers INRA and CNRS showed by genetic approaches that, in the model bacterium Bacillus subtilis, central carbon metabolism (which generates energy from nutrients) and replication (which synthesizes DNA), two key functions in the fields of nutrition and heredity, are tightly linked. The results appear in the May 16th issue of the online, peer-reviewed, open-access journal PLoS ONE.
The discovered link involves the activity of a small region of the central carbon metabolism (the terminal reactions of a process called glycolysis that burns sugars) and several enzymes of the replication machinery that synthesizes DNA. It is proposed that the link depends on metabolic signals generated as a function of the activity of the terminal reactions of glycolysis which are sensed, directly or indirectly, by replication enzymes. This system would then adjust the speed of DNA synthesis and the stability of the replication machinery to the nutritional richness of the environment, and thus to the cell’s growth rate.
These results, along with those integrating metabolism and, for instance, transcription, apoptosis and nervous flux, suggest that the central carbon metabolism plays a global regulatory function to adjust the activity of principal cellular functions to the richness of the available nutrients. This non metabolic function may explain why several enzymes of the central carbon metabolism are essential and strongly conserved in living organisms.
In addition to its fundamental interest, the metabolism/replication link may be of medical importance as early events in carcinogenesis, which generally include an up-regulation of glycolysis (the Warburg effect) and a decrease in DNA stability and replication fidelity, may involve perturbations of the metabolism/replication link.
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
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Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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