Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers discover how antibiotic inhibits bacterial growth

14.05.2007
Researchers at the University of Illinois at Chicago, in collaboration with research teams from Pharmacia & Upjohn and Pfizer, have discovered precisely how the antibiotic linezolid inhibits bacterial growth.

Scientists have known that the drug linezolid -- the first new antibiotic to enter the marketplace in 30 years -- works by binding to ribosomes, the protein production factory of the cell. But exactly where the binding occurred and how the drug worked was not known. Until now.

"Linezolid targets ribosomes, inhibits protein synthesis, and kills bacteria," said Alexander Mankin, professor and associate director of UIC's Center for Pharmaceutical Biotechnology and lead investigator of the study. "If we know exactly where the drug binds, we can make it better and learn how to use it more effectively."

Linezolid is a synthetic antibiotic used for the treatment of infections caused by pathogens such as staph and strep, including multi-drug-resistant bacteria. Skin infections, pneumonia, and other diseases can be treated with linezolid. It is marketed in the United States as Zyvox.

... more about:
»Linezolid »antibiotic »inhibits »ribosome

Mankin and his colleagues managed not only to crosslink the drug to its target in the living cell, but to precisely characterize the mode of binding of the drug to the ribosome.

"It was a combined effort of excellent chemists, structural biologists and biochemists," Mankin said.

"We now understand much better how the drug works, how it can be improved, and how bacteria can become resistant to linezolid."

A second part of the study involved learning why, in rare cases, the drug can have side effects causing a decrease in the production of blood cells. By crosslinking linezolid to its target in human cells, the researchers showed that the drug may be toxic to mitochondria -- the power generators of the cell -- which contain ribosomes that resemble the ribosomes of bacteria.

"This is the first time such detailed information about the linezolid target in the living cell has been obtained," Mankin said.

Sam Hostettler | EurekAlert!
Further information:
http://www.uic.edu

Further reports about: Linezolid antibiotic inhibits ribosome

More articles from Life Sciences:

nachricht Polymers Based on Boron?
18.01.2018 | Julius-Maximilians-Universität Würzburg

nachricht Bioengineered soft microfibers improve T-cell production
18.01.2018 | Columbia University School of Engineering and Applied Science

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

Im Focus: A thermometer for the oceans

Measurement of noble gases in Antarctic ice cores

The oceans are the largest global heat reservoir. As a result of man-made global warming, the temperature in the global climate system increases; around 90% of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Polymers Based on Boron?

18.01.2018 | Life Sciences

Bioengineered soft microfibers improve T-cell production

18.01.2018 | Life Sciences

World’s oldest known oxygen oasis discovered

18.01.2018 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>