Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Researchers discover how antibiotic inhibits bacterial growth

Researchers at the University of Illinois at Chicago, in collaboration with research teams from Pharmacia & Upjohn and Pfizer, have discovered precisely how the antibiotic linezolid inhibits bacterial growth.

Scientists have known that the drug linezolid -- the first new antibiotic to enter the marketplace in 30 years -- works by binding to ribosomes, the protein production factory of the cell. But exactly where the binding occurred and how the drug worked was not known. Until now.

"Linezolid targets ribosomes, inhibits protein synthesis, and kills bacteria," said Alexander Mankin, professor and associate director of UIC's Center for Pharmaceutical Biotechnology and lead investigator of the study. "If we know exactly where the drug binds, we can make it better and learn how to use it more effectively."

Linezolid is a synthetic antibiotic used for the treatment of infections caused by pathogens such as staph and strep, including multi-drug-resistant bacteria. Skin infections, pneumonia, and other diseases can be treated with linezolid. It is marketed in the United States as Zyvox.

... more about:
»Linezolid »antibiotic »inhibits »ribosome

Mankin and his colleagues managed not only to crosslink the drug to its target in the living cell, but to precisely characterize the mode of binding of the drug to the ribosome.

"It was a combined effort of excellent chemists, structural biologists and biochemists," Mankin said.

"We now understand much better how the drug works, how it can be improved, and how bacteria can become resistant to linezolid."

A second part of the study involved learning why, in rare cases, the drug can have side effects causing a decrease in the production of blood cells. By crosslinking linezolid to its target in human cells, the researchers showed that the drug may be toxic to mitochondria -- the power generators of the cell -- which contain ribosomes that resemble the ribosomes of bacteria.

"This is the first time such detailed information about the linezolid target in the living cell has been obtained," Mankin said.

Sam Hostettler | EurekAlert!
Further information:

Further reports about: Linezolid antibiotic inhibits ribosome

More articles from Life Sciences:

nachricht ‘Farming’ bacteria to boost growth in the oceans
24.10.2016 | Max-Planck-Institut für marine Mikrobiologie

nachricht Calcium Induces Chronic Lung Infections
24.10.2016 | Universität Basel

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Light-driven atomic rotations excite magnetic waves

Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion

Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...

Im Focus: New 3-D wiring technique brings scalable quantum computers closer to reality

Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.

"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...

Im Focus: Scientists develop a semiconductor nanocomposite material that moves in response to light

In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.

A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...

Im Focus: Diamonds aren't forever: Sandia, Harvard team create first quantum computer bridge

By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.

"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...

Im Focus: New Products - Highlights of COMPAMED 2016

COMPAMED has become the leading international marketplace for suppliers of medical manufacturing. The trade fair, which takes place every November and is co-located to MEDICA in Dusseldorf, has been steadily growing over the past years and shows that medical technology remains a rapidly growing market.

In 2016, the joint pavilion by the IVAM Microtechnology Network, the Product Market “High-tech for Medical Devices”, will be located in Hall 8a again and will...

All Focus news of the innovation-report >>>



Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

Agricultural Trade Developments and Potentials in Central Asia and the South Caucasus

14.10.2016 | Event News

World Health Summit – Day Three: A Call to Action

12.10.2016 | Event News

Latest News

Oasis of life in the ice-covered central Arctic

24.10.2016 | Earth Sciences

‘Farming’ bacteria to boost growth in the oceans

24.10.2016 | Life Sciences

Light-driven atomic rotations excite magnetic waves

24.10.2016 | Physics and Astronomy

More VideoLinks >>>