Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein interactions targets for Huntington disease therapy

14.05.2007
The identification of more than 200 new proteins that interact with the mutated protein that causes Huntington’s disease opens the door to developing treatments for the fatal neurodegenerative disorder, said a Baylor College of Medicine researcher who took part in the work that appears online today in the journal Public Library of Science Genetics.

BCM scientists actually determined which proteins among the list of more than 200 identified at Buck Institute modify the effect of the Huntington’s protein. The Buck Institute is located in Novato, California.

Huntington’s disease is a devastating, fatal neurological disorder that affects an estimated 30,000 Americans. It is dominantly inherited, which means that if a person inherits a single copy of the gene from a parent, that person will develop the disease – usually in middle age. Children born to parents who go on to develop Huntington’s disease have a 50:50 chance of having the disease themselves. Musician Woody Guthrie was among its best known sufferers.

“Many of the proteins that interact with Huntington’s are modulators of its toxicity,” said Dr. Juan Botas, associate professor of molecular and human genetics at BCM and a senior author of the paper. “This could also be a way to look for and identify factors that modulate a number of proteins involved in other neurodegenerative disease.”

... more about:
»Disease »Huntington’s »symptoms

Modulating means that the interacting protein affects the deadly symptoms caused by Huntington’s, he said. Some of the interactive proteins might cause a person to develop the disease later; others could actually make the symptoms appear earlier or to be more severe.

“When you tinker with some of these genes, you find that some of them improve the symptoms. These could be potential therapeutic targets,” said Botas. “When you tinker with others, it makes the Huntington’s more aggressive. These might be ones that accelerate the age of disease onset. Not everyone with Huntington’s develops symptoms at the same age.”

Botas and his colleagues used a fruit fly model of Huntington’s to test the proteins’ effects.

The sheer number of proteins identified could open the door to more studies farther down the line, he said.

Graciela Gutierrez | EurekAlert!
Further information:
http://www.bcm.edu

Further reports about: Disease Huntington’s symptoms

More articles from Life Sciences:

nachricht Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery
20.01.2017 | GSI Helmholtzzentrum für Schwerionenforschung GmbH

nachricht Seeking structure with metagenome sequences
20.01.2017 | DOE/Joint Genome Institute

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Traffic jam in empty space

New success for Konstanz physicists in studying the quantum vacuum

An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Sustainable Water use in Agriculture in Eastern Europe and Central Asia

19.01.2017 | Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

 
Latest News

Helmholtz International Fellow Award for Sarah Amalia Teichmann

20.01.2017 | Awards Funding

An innovative high-performance material: biofibers made from green lacewing silk

20.01.2017 | Materials Sciences

Ion treatments for cardiac arrhythmia — Non-invasive alternative to catheter-based surgery

20.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>