Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Lessons from ovarian cells migration: The three “Ws” of ovarian cancer spreading

14.05.2007
Who must go? When to go? Where to go? During development ovarian cells migrate in a spacial-temporal coordinated way, responding to specific signals that determine which cells have to move, when they have to move, and where they have to go.

The same types of signals stimulate migration of ovarian cancer cells, which follow specific signals to move from the female genital tract towards the peritoneum and stroma, where they form metastases. These findings were presented today (May 13th) by Denise Montell, Professor of Biological Chemistry at the Johns Hopkins University School of Medicine in Baltimore (Maryland), at the Workshop on Cell Migration: From Molecules to Organisms and Diseases promoted by the European School of Molecular Medicine (SEMM) and the University of Milan, in collaboration with IFOM – The FIRC Institute for Molecular Oncology of the Italian Foundation for Cancer Research, and IEO – European Institute of Oncology. Venue of the Workshop is the IFOM-IEO Campus (via Adamello, 16, Milan) that was recently opened and represents the biggest area dedicated to the oncological research in Europe.

Epithelial ovarian cancer (EOC) develops in the ovary, especially in the cells that cover the outer surface of this organ. As it scores 190,000 new cases each year worldwide (61,000 in Europe), it has fuelled intensive investigations all over the world. Denise Montell and her group have been studying cell migration for years, in the attempt to elucidate the key elements that govern their movement. To this purpose the scientists have set up a system called “border cells model”, employing fruit fly (Drosophila melanogaster) cells, which has led to the identification of specific regulatory signals that cells respond to. “Epithelial cells migrate in a way that is reminiscent of the migratory behavior of cancer cells - explains the scientists – and this moving is highly coordinated as it responds to extracellular signals present in the surrounding microenvironment. Using our experimental model we were able to identify three kinds of signals.”

They are:

... more about:
»Migration »Montell »ovarian »signals
- When: steroid hormones dictate the time when cells must start moving;
- Where: Growth Factors show them the right direction;
- Who: compounds called cytokines determine which cells will acquire mobility.

“Each of these signals – continues Montell – must work together in order for the cells to proceed to their correct destination. But they are not the only ones”. Further investigations into the signaling pathway of ovarian cells, in fact, led Montell to identify Par-1 as a key gene that controls cells migration. “We found – says Montell – that Par-1 regulates the detachment of cells from the epithelium and a critical step in releasing the cells from the original tissue”. Along these lines, future goal of the scientists will be to determine whether Par-1 contributes to ovarian cancer metastasis, or that of other carcinomas.

“Basic science results such as Montell’s have great value – points out Marina Mione, head of the IFOM program Genetic control of cell migration in zebrafish, and member of the Workshop’s Scientific Committee – as they pave the way for future clinical application. Devising new therapeutic approaches implies previous acquisition of solid scientific baseline information. Moving from observations acquired in physiological conditions Montell opens a number of new avenues that will promote our understanding of pathological conditions”.

Francesca Noceti | alfa
Further information:
http://www.semm.it/workshop/cellmig07/

Further reports about: Migration Montell ovarian signals

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

DGIST develops 20 times faster biosensor

24.04.2017 | Physics and Astronomy

Nanoimprinted hyperlens array: Paving the way for practical super-resolution imaging

24.04.2017 | Materials Sciences

Atomic-level motion may drive bacteria's ability to evade immune system defenses

24.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>