Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Lessons from ovarian cells migration: The three “Ws” of ovarian cancer spreading

14.05.2007
Who must go? When to go? Where to go? During development ovarian cells migrate in a spacial-temporal coordinated way, responding to specific signals that determine which cells have to move, when they have to move, and where they have to go.

The same types of signals stimulate migration of ovarian cancer cells, which follow specific signals to move from the female genital tract towards the peritoneum and stroma, where they form metastases. These findings were presented today (May 13th) by Denise Montell, Professor of Biological Chemistry at the Johns Hopkins University School of Medicine in Baltimore (Maryland), at the Workshop on Cell Migration: From Molecules to Organisms and Diseases promoted by the European School of Molecular Medicine (SEMM) and the University of Milan, in collaboration with IFOM – The FIRC Institute for Molecular Oncology of the Italian Foundation for Cancer Research, and IEO – European Institute of Oncology. Venue of the Workshop is the IFOM-IEO Campus (via Adamello, 16, Milan) that was recently opened and represents the biggest area dedicated to the oncological research in Europe.

Epithelial ovarian cancer (EOC) develops in the ovary, especially in the cells that cover the outer surface of this organ. As it scores 190,000 new cases each year worldwide (61,000 in Europe), it has fuelled intensive investigations all over the world. Denise Montell and her group have been studying cell migration for years, in the attempt to elucidate the key elements that govern their movement. To this purpose the scientists have set up a system called “border cells model”, employing fruit fly (Drosophila melanogaster) cells, which has led to the identification of specific regulatory signals that cells respond to. “Epithelial cells migrate in a way that is reminiscent of the migratory behavior of cancer cells - explains the scientists – and this moving is highly coordinated as it responds to extracellular signals present in the surrounding microenvironment. Using our experimental model we were able to identify three kinds of signals.”

They are:

... more about:
»Migration »Montell »ovarian »signals
- When: steroid hormones dictate the time when cells must start moving;
- Where: Growth Factors show them the right direction;
- Who: compounds called cytokines determine which cells will acquire mobility.

“Each of these signals – continues Montell – must work together in order for the cells to proceed to their correct destination. But they are not the only ones”. Further investigations into the signaling pathway of ovarian cells, in fact, led Montell to identify Par-1 as a key gene that controls cells migration. “We found – says Montell – that Par-1 regulates the detachment of cells from the epithelium and a critical step in releasing the cells from the original tissue”. Along these lines, future goal of the scientists will be to determine whether Par-1 contributes to ovarian cancer metastasis, or that of other carcinomas.

“Basic science results such as Montell’s have great value – points out Marina Mione, head of the IFOM program Genetic control of cell migration in zebrafish, and member of the Workshop’s Scientific Committee – as they pave the way for future clinical application. Devising new therapeutic approaches implies previous acquisition of solid scientific baseline information. Moving from observations acquired in physiological conditions Montell opens a number of new avenues that will promote our understanding of pathological conditions”.

Francesca Noceti | alfa
Further information:
http://www.semm.it/workshop/cellmig07/

Further reports about: Migration Montell ovarian signals

More articles from Life Sciences:

nachricht How brains surrender to sleep
23.06.2017 | IMP - Forschungsinstitut für Molekulare Pathologie GmbH

nachricht A new technique isolates neuronal activity during memory consolidation
22.06.2017 | Spanish National Research Council (CSIC)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Quantum thermometer or optical refrigerator?

23.06.2017 | Physics and Astronomy

A 100-year-old physics problem has been solved at EPFL

23.06.2017 | Physics and Astronomy

Equipping form with function

23.06.2017 | Information Technology

VideoLinks
B2B-VideoLinks
More VideoLinks >>>