The same types of signals stimulate migration of ovarian cancer cells, which follow specific signals to move from the female genital tract towards the peritoneum and stroma, where they form metastases. These findings were presented today (May 13th) by Denise Montell, Professor of Biological Chemistry at the Johns Hopkins University School of Medicine in Baltimore (Maryland), at the Workshop on Cell Migration: From Molecules to Organisms and Diseases promoted by the European School of Molecular Medicine (SEMM) and the University of Milan, in collaboration with IFOM – The FIRC Institute for Molecular Oncology of the Italian Foundation for Cancer Research, and IEO – European Institute of Oncology. Venue of the Workshop is the IFOM-IEO Campus (via Adamello, 16, Milan) that was recently opened and represents the biggest area dedicated to the oncological research in Europe.
Epithelial ovarian cancer (EOC) develops in the ovary, especially in the cells that cover the outer surface of this organ. As it scores 190,000 new cases each year worldwide (61,000 in Europe), it has fuelled intensive investigations all over the world. Denise Montell and her group have been studying cell migration for years, in the attempt to elucidate the key elements that govern their movement. To this purpose the scientists have set up a system called “border cells model”, employing fruit fly (Drosophila melanogaster) cells, which has led to the identification of specific regulatory signals that cells respond to. “Epithelial cells migrate in a way that is reminiscent of the migratory behavior of cancer cells - explains the scientists – and this moving is highly coordinated as it responds to extracellular signals present in the surrounding microenvironment. Using our experimental model we were able to identify three kinds of signals.”
“Basic science results such as Montell’s have great value – points out Marina Mione, head of the IFOM program Genetic control of cell migration in zebrafish, and member of the Workshop’s Scientific Committee – as they pave the way for future clinical application. Devising new therapeutic approaches implies previous acquisition of solid scientific baseline information. Moving from observations acquired in physiological conditions Montell opens a number of new avenues that will promote our understanding of pathological conditions”.
Francesca Noceti | alfa
Modern genetic sequencing tools give clearer picture of how corals are related
17.08.2017 | University of Washington
The irresistible fragrance of dying vinegar flies
16.08.2017 | Max-Planck-Institut für chemische Ökologie
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
17.08.2017 | Physics and Astronomy
17.08.2017 | Earth Sciences
17.08.2017 | Physics and Astronomy