The USF study, published in the March 2007 issue of the journal Developmental Biology and highlighted April 26, 2007 in Nature, counters the controversial findings of reproductive endocrinologist Jonathan Tilly, PhD, and his team of Harvard scientists. Tilly’s work, published in 2004 in Nature with a follow-up study a year later in Cell, challenged the biological dogma that mammals, including women, are born with a limited lifetime supply of eggs.
Tilly reported the discovery of stem cells capable of migrating from bone marrow to mouse ovaries and generating new eggs there. The research fueled hopes that a new treatment – such as bone marrow transplantation – might one day help older women regain their fertility.
Since then, other papers have refuted Tilly’s surprising finding that mice can produce eggs throughout their lives. Now, David Keefe, MD, professor and chair of Obstetrics and Gynecology at USF, and colleague Lin Liu, who also holds a post at Sun Yat-Sen University in Guangzhou, China, say they can find no evidence to support his hypothesis that women may generate new eggs after birth.
The USF researchers searched for markers of stem cells or of meiotic cell division in ovarian cells biopsied from 12 women between the ages of 28 and 53.
“Despite using the most sensitive methods available, we found no evidence of any egg stem cells in human ovaries, demonstrating that Dr. Tilly’s findings in mice do not apply to women,” Dr. Keefe said. “Dr. Tilly likely was seeing non-egg cells which resemble eggs. Another reason his findings do not apply to women could be because mice eggs are more resilient than women’s eggs. The bottom line is that women should not expect stem cell therapy to treat egg infertility or menopause in the foreseeable future.”
“This is a very important finding by a distinguished group of researchers and clinician-scientists at USF Health which affirms the traditional dogma of a finite period of fertility in women,” said Abdul S. Rao, MD, MA, DPhil, senior associate vice president for USF Health and vice dean for research and graduate affairs at the College of Medicine.
The traditional view of fertility holds that women are born with all their eggs and they are released one by one (occasionally two) at each ovulation. At menopause, few to no mature eggs are believed to remain in the ovaries.
USF Health is a partnership of the University of South Florida’s colleges of medicine, nursing, and public health; the schools of basic biomedical sciences and physical therapy & rehabilitation sciences; and the USF Physicians Group. It is a partnership dedicated to the promise of creating a new model of health and health care. One of the nation’s top 63 public research universities as designated by the Carnegie Foundation for the Advancement of Teaching, USF received more than $310 million in research contracts and grants last year. It is ranked by the National Science Foundation as one of the nation’s fastest growing universities for federal research and development expenditures.
Anne DeLotto Baier | EurekAlert!
Less is more? Gene switch for healthy aging found
25.05.2018 | Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI)
If solubilty is the problem - Mechanochemistry is the solution
25.05.2018 | Technische Universität Dresden
A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.
The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
25.05.2018 | Life Sciences
25.05.2018 | Interdisciplinary Research
24.05.2018 | Ecology, The Environment and Conservation