The results, the first from nonhuman primates, are similar to those previously seen in rodents. They suggest that creation of new nerve cells, a process known as neurogenesis, is an important part of antidepressant therapy. Researcher Tarique Perera, MD, at Columbia University, and colleagues observed changes in the number of brain cells in the dentate gyrus region of the hippocampus. The study is published in the May 2 issue of The Journal of Neuroscience.
The growth of new nerve cells in the hippocampus has been suggested as the way antidepressants work in rodents, says Eric Nestler, MD, PhD, of the University of Texas Southwestern Medical Center. "However, the clinical relevance of this action has remained controversial, in part, because of uncertainty as to whether similar neurogenesis occurs in humans," he says. "This finding further supports the potential clinical relevance of changes in neurogenesis seen in rodent models."
Perera and the team treated a group of monkeys with electroconvulsive shock (ECS), an animal version of the highly effective clinical antidepressant electroconvulsive therapy. They saw an increase in new nerve cells in the hippocampus. Over four weeks, a majority of these cells became mature neurons.
These brain changes were not a response to tissue damage, Perera says, because no evidence of increased cell death was found in the ECS treated animals. In fact, the researchers found that the ECS treatments increased production of a protein (BCL2) that protects neurons from damage.
"These findings support the hypothesis that induction of neurogenesis is a necessary component in the mechanism of action of antidepressant treatments," Perera says.
Sara Harris | EurekAlert!
The balancing act: An enzyme that links endocytosis to membrane recycling
07.12.2016 | National Centre for Biological Sciences
Transforming plant cells from generalists to specialists
07.12.2016 | Duke University
In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.
Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...
Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...
A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.
Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...
In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.
“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...
The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.
The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...
16.11.2016 | Event News
01.11.2016 | Event News
14.10.2016 | Event News
07.12.2016 | Health and Medicine
07.12.2016 | Life Sciences
07.12.2016 | Health and Medicine