The genes were found by Dr. Vasiliki Theodorou in the research group of Dr. John Hilkens in an exhaustive screen for new oncogenes by using mouse mammary tumor virus-based insertional mutagenesis, an existing technology that obtained a new impuls as a result of the recent completion of the mouse genome sequence. The technology is based on the property of retroviruses to incorporate their DNA in the genome of the host cell as part of their live cycle. The incorporated DNA behaves as a mutagen and affects the activity of adjacent genes or interrupts the coding sequence of a host cell gene. If the affected gene is an oncogene, the integration can lead to tumor development.
Because the genetic code is known the integration site of the viral DNA can be exactly be located. Subsequently, the gene that is affected by the inserted virus can be identified. It is the first time that so many genes were identified in this way.
Theodorou and collegues looked for breast cancer genes in a mouse model. Breast cancer research in mice provide us more insight in development of human breast cancer and aid reseachers in the development of new therapies.
Frederique Melman | alfa
Scientists unlock ability to generate new sensory hair cells
22.02.2017 | Brigham and Women's Hospital
New insights into the information processing of motor neurons
22.02.2017 | Max Planck Florida Institute for Neuroscience
In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
22.02.2017 | Power and Electrical Engineering
22.02.2017 | Life Sciences
22.02.2017 | Physics and Astronomy