Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Study of damaged gene gives insight into causes of mental illness

03.05.2007
Scientists have pinpointed how different types of damage to the same gene can cause some people to suffer from schizophrenia while others have major depression

Scientists have pinpointed how different types of damage in types of damage to the same gene can cause some people to suffer from schizophrenia while others have major depression.

The findings which are published in the journal Neuron, provide further evidence that these illnesses are inherited, and may in the future help doctors pinpoint which patients will respond to different types of treatments.

Experts from the University of Edinburgh, working with researchers from Mount Sinai Hospital in Toronto, Canada and RIKEN in Japan, studied two types of damage to a gene (DISC1). Previous research at the University, working with families with a high incidence of mental illness, identified this gene as being linked to schizophrenia, manic depression (bipolar affective disorder) and major depression. The gene was also found to be essential for brain signalling and plays a key role in learning, memory and mood.

... more about:
»DISC1 »Depression »Mental »disorder »schizophrenia »types

To further their findings, experts looked at the behaviour of mice with two types of damage in the gene. The results suggest that one responded better to antipsychotics, used to treat schizophrenia while the other responded better to anti-depressants, used to treat mood disorders.

Prof David Porteous, Chair of Human Molecular Genetics and Medicine at the University of Edinburgh, said: “While the causes of schizophrenia, bipolar affective disorder and major depression are unknown, all the evidence points to subtle differences in the way the brain develops and to chemical changes in the brain. Our previous work identified the DISC1 gene as an important risk factor in these types of mental illness.

“By analysing the behaviour of mice, we were able to provide further evidence of the importance of DISC1. We also found remarkable clear cut differences between the different types of damage to the gene and the treatment that was the most effective. By analysing how the brain changes and develops over time we would hope that this would lead to more effective drugs to treat such illnesses.”

About one in 50 people worldwide will develop the symptoms of schizophrenia or bipolar affective disorder, with the first signs often appearing in late adolescence or early adulthood. Most cases arise in families with some sort of history of mental illness implying a strong influence of genes. Several different genes have been reported to pre-dispose to schizophrenia but DISC1 is one of the few which has been replicated by several laboratories.

Tara Womersley | EurekAlert!
Further information:
http://www.ed.ac.uk

Further reports about: DISC1 Depression Mental disorder schizophrenia types

More articles from Life Sciences:

nachricht Complementing conventional antibiotics
24.05.2018 | Goethe-Universität Frankfurt am Main

nachricht Building a brain, cell by cell: Researchers make a mini neuron network (of two)
23.05.2018 | Institute of Industrial Science, The University of Tokyo

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

When corals eat plastics

24.05.2018 | Ecology, The Environment and Conservation

Surgery involving ultrasound energy found to treat high blood pressure

24.05.2018 | Medical Engineering

First chip-scale broadband optical system that can sense molecules in the mid-IR

24.05.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>