Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Molecular Rendezvous Caught on Camera

02.05.2007
Scientists watch on the atomic level how individual molecules recognize each other

The body is an almost perfect machine. For it to function properly, each individual component, that is each molecule, must reliably fulfill its specific function. Each molecule must thus “recognize” other molecules and work with them. A team of researchers from the Max Planck Institute for Solid State Research in Stuttgart, the Fraunhofer Institute in Freiburg, and King’s College in London, has now successfully filmed pairs of molecules during the recognition process. As reported to the journal Angewandte Chemie, the shapes of the molecules change to accommodate each other.

Like humans, molecules also “greet” each other with a kind of “handshake”. Anyone who has tried to shake someone’s right hand with his or her own left will have had a little trouble: the right and left hands do not fit together. In the same way, some molecules that exist in both a right-handed (D) and left-handed (L) configuration can tell if others they encounter are the D or L form.

Magali Lingenfelder and colleagues at the Max Planck Institute for Solid State Research have now been able to use scanning tunneling microscopy to take a series of pictures that follow in detail the “encounters” of diphenylalanine molecules adsorbed onto a substrate. (Diphenylalanine is the central structural unit within polypeptide fibers found in the brains of Alzheimer’s patients.) The “film sequences” reveal that only molecules with the same chirality (handedness) readily aggregate into pairs and chains.

Just as in a handshake, it is not enough that the right hands hold each other. To grip each other firmly, the two hands must adapt to fit their shapes together. Molecules do the same: close examination of the “film”, in conjunction with theoretical calculations by researchers from King’s College, prove that this type of dynamic accommodation of shape also occurs when two molecules “shake hands”.

“Our work finally demonstrates that Linus Pauling was right with his theory of intermolecular conformation of over 50 years ago,” says Lingenfelder. “In molecular recognition, it is not so much the static forms that are important, but rather how well the molecules can conform to each other.”

Author: Magalí Lingenfelder, Max-Planck-Institut für Festkörperforschung, Stuttgart (Germany), http://www.fkf.mpg.de/kern/res_team/index.html

Title: Tracking the Chiral Recognition of Adsorbed Dipeptides at the Single-Molecule Level

Angewandte Chemie International Edition, doi: 10.1002/anie.200700194

| Angewandte Chemie
Further information:
http://www.fkf.mpg.de/kern/res_team/index.html
http://pressroom.angewandte.org.

Further reports about: Angewandte Chemie Lingenfelder Max Planck Institute

More articles from Life Sciences:

nachricht Researchers uncover protein-based “cancer signature”
05.12.2016 | Universität Basel

nachricht The Nagoya Protocol Creates Disadvantages for Many Countries when Applied to Microorganisms
05.12.2016 | Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Researchers uncover protein-based “cancer signature”

05.12.2016 | Life Sciences

The Nagoya Protocol Creates Disadvantages for Many Countries when Applied to Microorganisms

05.12.2016 | Life Sciences

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>