Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Molecular Rendezvous Caught on Camera

02.05.2007
Scientists watch on the atomic level how individual molecules recognize each other

The body is an almost perfect machine. For it to function properly, each individual component, that is each molecule, must reliably fulfill its specific function. Each molecule must thus “recognize” other molecules and work with them. A team of researchers from the Max Planck Institute for Solid State Research in Stuttgart, the Fraunhofer Institute in Freiburg, and King’s College in London, has now successfully filmed pairs of molecules during the recognition process. As reported to the journal Angewandte Chemie, the shapes of the molecules change to accommodate each other.

Like humans, molecules also “greet” each other with a kind of “handshake”. Anyone who has tried to shake someone’s right hand with his or her own left will have had a little trouble: the right and left hands do not fit together. In the same way, some molecules that exist in both a right-handed (D) and left-handed (L) configuration can tell if others they encounter are the D or L form.

Magali Lingenfelder and colleagues at the Max Planck Institute for Solid State Research have now been able to use scanning tunneling microscopy to take a series of pictures that follow in detail the “encounters” of diphenylalanine molecules adsorbed onto a substrate. (Diphenylalanine is the central structural unit within polypeptide fibers found in the brains of Alzheimer’s patients.) The “film sequences” reveal that only molecules with the same chirality (handedness) readily aggregate into pairs and chains.

Just as in a handshake, it is not enough that the right hands hold each other. To grip each other firmly, the two hands must adapt to fit their shapes together. Molecules do the same: close examination of the “film”, in conjunction with theoretical calculations by researchers from King’s College, prove that this type of dynamic accommodation of shape also occurs when two molecules “shake hands”.

“Our work finally demonstrates that Linus Pauling was right with his theory of intermolecular conformation of over 50 years ago,” says Lingenfelder. “In molecular recognition, it is not so much the static forms that are important, but rather how well the molecules can conform to each other.”

Author: Magalí Lingenfelder, Max-Planck-Institut für Festkörperforschung, Stuttgart (Germany), http://www.fkf.mpg.de/kern/res_team/index.html

Title: Tracking the Chiral Recognition of Adsorbed Dipeptides at the Single-Molecule Level

Angewandte Chemie International Edition, doi: 10.1002/anie.200700194

| Angewandte Chemie
Further information:
http://www.fkf.mpg.de/kern/res_team/index.html
http://pressroom.angewandte.org.

Further reports about: Angewandte Chemie Lingenfelder Max Planck Institute

More articles from Life Sciences:

nachricht 'Lipid asymmetry' plays key role in activating immune cells
20.02.2018 | Biophysical Society

nachricht New printing technique uses cells and molecules to recreate biological structures
20.02.2018 | Queen Mary University of London

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

Im Focus: Interference as a new method for cooling quantum devices

Theoretical physicists propose to use negative interference to control heat flow in quantum devices. Study published in Physical Review Letters

Quantum computer parts are sensitive and need to be cooled to very low temperatures. Their tiny size makes them particularly susceptible to a temperature...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

'Lipid asymmetry' plays key role in activating immune cells

20.02.2018 | Life Sciences

MRI technique differentiates benign breast lesions from malignancies

20.02.2018 | Medical Engineering

Major discovery in controlling quantum states of single atoms

20.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>