Several T cell subsets with immunosuppressive functions have been reported to demonstrate their suppressive capabilities to the acquired immune system in animal autoimmune disease models. Among them, CD4+ T cells constitutively expressing CD25, termed CD4+CD25+ regulatory (Treg) cells, are considered to be the major controllers of autoreactive T cells, thus maintaining immunological self-tolerance. The human equivalent was identified in CD4+ T cells expressing only high levels of CD25 (CD4+CD25high regulatory T (Treg) cells).
This study examined the number and function of CD4+CD25high Treg cells in PV. Peripheral blood mononuclear cells were prepared from PV patients as well as normal and disease control volunteers, and the frequency and phenotypes of T cells were determined by flow cytometry. CD4+CD25+ and CD4+CD25- T cells isolated from peripheral blood mononuclear cells of PV patients and normal controls were subjected to real-time semiquantitative RT-PCR for the expression of Foxp3 gene.
The proportion of T cells in all PV patients was severely reduced, approximately ten times less than in controls. These observations were further confirmed by both diminished gene and protein expression of Foxp3 in the CD4+CD25+ T cell population in PV patients. However, additional studies are needed to further clarify the role of T cells in the pathogenesis of PV.
Carla Holmes | alfa
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28.03.2017 | University of California - Riverside
The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.
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Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
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