In 2006 in Europe, an estimated 345,900 prostate cancer cases were diagnosed. In Sweden with nearly 10,000 new cases of prostate cancer per year, this is the most common form of cancer among men in Sweden. The disease often develops slowly, but the proportion of more aggressive forms of prostate cancer is growing. The fungal compound galiellalactone could be used against tumors that cannot be treated with surgery or radiation and does not respond to hormone treatment.
"In our trials this compound has curbed the growth of prostate cancer cells both in animal experiments and in laboratory experiments," says the researcher Rebecka Hellsten. The research team she belongs to was recently granted SEK 1.3 million from the Holger K. Christiansen Foundation in Denmark. The team consists of Dr. Rebecka Hellsten and Professor Anders Bjartell from the Section for Urological Cancer Research at the University Hospital in Malmö and Professor Olov Sterner and Dr. Martin Johansson from the Section for Organic Chemistry at Lund University.
Olov Sterner and his associates do research on organic molecules from plants, fungi, and marine organisms, and how they can be used in the development of drugs or industrially useful substances. They have developed a synthetic method for producing the fungal compound and will now attempt to tweak the substance to make it even more effective against tumor cells.
The mushroom the substance originates from is called Galiella rufa, which grows in clusters on old wood in eastern North America. The fungi are bowl-shaped, dark on the outside, reddish yellow on the inside, and a few centimeters across. It was discovered that this particular mushroom can be used to fight prostate cancer in connection with a study run by a German research team, when they were testing extracts from various species of fungi to find substances that could disrupt a certain signaling pathway in human cells.
"The German scientists were not thinking about prostate cancer, but the signaling pathway the study targeted is also relevant to these particular tumor cells. If we can alter the fungal substance synthetically so it impacts the signaling in tumor cells even more effectively, we could have a drug for tumors that we can't deal with today," says Rebecka Hellsten.
More information: Rebecka Hellsten, phone: +46 (0)40-337903 or email:Rebecka.Hellsten@med.lu.se.
Ingela Björck | idw
Single-stranded DNA and RNA origami go live
15.12.2017 | Wyss Institute for Biologically Inspired Engineering at Harvard
New antbird species discovered in Peru by LSU ornithologists
15.12.2017 | Louisiana State University
DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...
MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.
Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...
Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...
Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.
To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
11.12.2017 | Event News
08.12.2017 | Event News
07.12.2017 | Event News
15.12.2017 | Power and Electrical Engineering
15.12.2017 | Materials Sciences
15.12.2017 | Life Sciences