Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Something fishy in human blood could save lives

02.04.2007
New research in the FASEB journal offers hope for people with liver and kidney damage

Thousands of people with liver and kidney disease die every year from too much ammonia in their blood, and scientists from the United States and Japan have found a possible solution. In the April 2007 issue of The FASEB Journal they report that a protein which excretes ammonia through pufferfish gills is similar to human Rh blood proteins. By targeting human Rh proteins, new treatments will help people with damaged livers and kidneys remove toxic ammonia from their bloodstream.

"Rh proteins are important targets for treatment of high toxic blood ammonia levels that occur in liver disease," said Shigehisa Hirose, co-author of the study. "Our findings also indicate that the ammonia transport system involving Rh glycoproteins is evolutionally conserved in a broad range of organisms, suggesting an essential role for surviving."

For people with kidney and liver damage, the need to remove naturally occurring ammonia from the bloodstream is critical. Brain cells are particularly susceptible to ammonia, and at low levels, ammonia toxicity can cause mild to severe confusion, drowsiness, or tremors. At high levels, ammonia toxicity leads to coma and eventually death. Rh blood proteins are most commonly recognized as being used to help define blood type. For instance, people who are type A, B, AB, or O positive have Rh blood proteins on the surface of their red blood cells. People who are type A, B, AB, or O negative do not have Rh proteins on the surface of their red blood cells.

... more about:
»Kidney »ammonia »blood protein

"This study has broad implications for practically any disease or trauma affecting the liver or kidneys," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "And the evolutionary implications make it even more compelling—hook, line, and sinker."

In addition to describing a new target for removing ammonia from the body, this study describes how fish gills are able to excrete ammonia at the molecular level using Rh proteins. This finding, when combined with the presence of Rh proteins in numerous organisms, adds a piece to the evolutionary puzzle, by suggesting that Rh proteins were developed very early in the evolution of animal systems, and continue to play an important role in removing toxic ammonia.

Cody Mooneyhan | EurekAlert!
Further information:
http://www.fasebj.org

Further reports about: Kidney ammonia blood protein

More articles from Life Sciences:

nachricht Designer cells: artificial enzyme can activate a gene switch
22.05.2018 | Universität Basel

nachricht Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Turning entanglement upside down

23.05.2018 | Physics and Astronomy

Designer cells: artificial enzyme can activate a gene switch

22.05.2018 | Life Sciences

PR of MCC: Carbon removal from atmosphere unavoidable for 1.5 degree target

22.05.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>