Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Polymers show promise for gene delivery, tissue scaffolds, other biomedical applications

28.03.2007
Virginia Tech polymer scientists have developed a new family of gene vectors – novel polymers that can ferry genetic material across the cell membrane so that it can be incorporated into the machinery of the cell.

Representing Virginia Tech faculty members and students from engineering, chemistry, and veterinary medicine, Chemistry Professor Tim Long will give an invited lecture at the 233rd National Meeting of the American Chemical Society in Chicago March 25-29.

The presentation will be an overview of novel polymers developed by Virginia Tech researchers for biomedical applications, with an emphasis on gene delivery and tissue scaffolds. “Both of these emerging technologies are enabled with fundamental advances in polymer chemistry,” Long said.

“Synthetic macromolecules can be easily modified to contain a variety of functional elements capable of interacting with biological systems,” he said. “Initial studies have found macromolecular topology to be a significant parameter in the delivery of DNA into cells.”

... more about:
»Biomedical »Polymer »scaffolds »vectors

In the cell, the new DNA initiates the manufacture of therapeutic proteins, such as might be needed to treat a genetic disease where an enzyme or protein is not produced naturally. The Virginia Tech vectors presently being tested in cell cultures are proving to be superior to surfactant benchmarks and offer reduced toxicity to viral vectors, Long said.

Meanwhile, scientists at Virginia Tech have developed a single-step process for creating fibrous mats from a small organic molecule – a new nanoscale, biocompatible material (Jan. 20, 2006, Science, "Phospholipid Nonwoven Electrospun Membranes," by Matthew G. McKee, John M. Layman, Matthew P. Cashion, and. Long, all at Virginia Tech.).

Since last year, they have improved the durability of the phospholipids through novel photochemistry during electrospinning and have begun to impregnate the porous mats with cells that will initiate tissue regeneration.

Susan Trulove | EurekAlert!
Further information:
http://www.vt.edu

Further reports about: Biomedical Polymer scaffolds vectors

More articles from Life Sciences:

nachricht More genes are active in high-performance maize
19.01.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht How plants see light
19.01.2018 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>