Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Light-activated therapy targets DNA components

28.03.2007
Chemists and biologists at Virginia Tech continuing to design light-activated molecular systems to attack cancer cells have introduced a DNA targeting component.

They will present the research at the 233rd national meeting of the American Chemical Society in Chicago March 25-29.

“We use visible light to signal the synthesized bioactive molecules to cleave DNA,” said Karen Brewer, professor of chemistry at Virginia Tech. “Incorporating a DNA target allows more selectivity. Coupling of the DNA targeting unit allows us to produce colored DNA-Complex assemblies that are easily photoactivated with visible light."

Avijita Jain of Bhopal, India, a Ph.D. candidate in chemistry at Virginia Tech, has designed a selective complex shown to inhibit growth in E. coli bacteria.

... more about:
»CHEMISTRY »DNA »Molecule

The group’s previous work included delivering the anticancer drug cisplatin and improved compounds to a disease site. In the process, the coupling of the drugs to the designed molecule increased water solubility. The improved selectivity along with photoinitiation reduce damage to healthy tissue.

The paper, “Synthesis, characterization, DNA binding and in vivo activity of Ru(II)/Pt(II) complexes” (INOR 690), will be presented at 1:50 p.m. Tuesday, March 27, at McCormick Place Lakeside room E253D by Jain. Co-authors are Brenda S. J. Winkel, professor of Biological Sciences at Virginia Tech, and Brewer.

Jain received her undergraduate degree from Barkatullah University Bhopal, M.P., India, and her master’s degree from Tennessee Technological University.

Aspects of DNA photocleavage ability of the new molecules will also be presented in the paper, “Coupling Ru or Os light absorbers to reactive Pt complexes: Excited state reactivity and DNA photocleavage” (INOR 1200), at 2:30 p.m., Wednesday, March 28, at McCormick Place Lakeside room E253D by Virginia Tech Ph.D. chemistry student Ran Miao of Zhangzhou City, China. Co-authors are chemistry graduate students David F. Zigler of Sterling, Illinois, and Jared Brown of Salem, Va., and Brewer.

Susan Trulove | EurekAlert!
Further information:
http://www.vt.edu

Further reports about: CHEMISTRY DNA Molecule

More articles from Life Sciences:

nachricht The birth of a new protein
20.10.2017 | University of Arizona

nachricht Building New Moss Factories
20.10.2017 | Albert-Ludwigs-Universität Freiburg im Breisgau

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Terahertz spectroscopy goes nano

20.10.2017 | Information Technology

Strange but true: Turning a material upside down can sometimes make it softer

20.10.2017 | Materials Sciences

NRL clarifies valley polarization for electronic and optoelectronic technologies

20.10.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>