They will present the research at the 233rd national meeting of the American Chemical Society in Chicago March 25-29.
“We use visible light to signal the synthesized bioactive molecules to cleave DNA,” said Karen Brewer, professor of chemistry at Virginia Tech. “Incorporating a DNA target allows more selectivity. Coupling of the DNA targeting unit allows us to produce colored DNA-Complex assemblies that are easily photoactivated with visible light."
Avijita Jain of Bhopal, India, a Ph.D. candidate in chemistry at Virginia Tech, has designed a selective complex shown to inhibit growth in E. coli bacteria.
The group’s previous work included delivering the anticancer drug cisplatin and improved compounds to a disease site. In the process, the coupling of the drugs to the designed molecule increased water solubility. The improved selectivity along with photoinitiation reduce damage to healthy tissue.
The paper, “Synthesis, characterization, DNA binding and in vivo activity of Ru(II)/Pt(II) complexes” (INOR 690), will be presented at 1:50 p.m. Tuesday, March 27, at McCormick Place Lakeside room E253D by Jain. Co-authors are Brenda S. J. Winkel, professor of Biological Sciences at Virginia Tech, and Brewer.
Jain received her undergraduate degree from Barkatullah University Bhopal, M.P., India, and her master’s degree from Tennessee Technological University.
Aspects of DNA photocleavage ability of the new molecules will also be presented in the paper, “Coupling Ru or Os light absorbers to reactive Pt complexes: Excited state reactivity and DNA photocleavage” (INOR 1200), at 2:30 p.m., Wednesday, March 28, at McCormick Place Lakeside room E253D by Virginia Tech Ph.D. chemistry student Ran Miao of Zhangzhou City, China. Co-authors are chemistry graduate students David F. Zigler of Sterling, Illinois, and Jared Brown of Salem, Va., and Brewer.
Susan Trulove | EurekAlert!
Designer cells: artificial enzyme can activate a gene switch
22.05.2018 | Universität Basel
Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.
At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...
There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?
At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
23.05.2018 | Physics and Astronomy
23.05.2018 | Agricultural and Forestry Science
23.05.2018 | Physics and Astronomy