They will present the research at the 233rd national meeting of the American Chemical Society in Chicago March 25-29.
“We use visible light to signal the synthesized bioactive molecules to cleave DNA,” said Karen Brewer, professor of chemistry at Virginia Tech. “Incorporating a DNA target allows more selectivity. Coupling of the DNA targeting unit allows us to produce colored DNA-Complex assemblies that are easily photoactivated with visible light."
Avijita Jain of Bhopal, India, a Ph.D. candidate in chemistry at Virginia Tech, has designed a selective complex shown to inhibit growth in E. coli bacteria.
The group’s previous work included delivering the anticancer drug cisplatin and improved compounds to a disease site. In the process, the coupling of the drugs to the designed molecule increased water solubility. The improved selectivity along with photoinitiation reduce damage to healthy tissue.
The paper, “Synthesis, characterization, DNA binding and in vivo activity of Ru(II)/Pt(II) complexes” (INOR 690), will be presented at 1:50 p.m. Tuesday, March 27, at McCormick Place Lakeside room E253D by Jain. Co-authors are Brenda S. J. Winkel, professor of Biological Sciences at Virginia Tech, and Brewer.
Jain received her undergraduate degree from Barkatullah University Bhopal, M.P., India, and her master’s degree from Tennessee Technological University.
Aspects of DNA photocleavage ability of the new molecules will also be presented in the paper, “Coupling Ru or Os light absorbers to reactive Pt complexes: Excited state reactivity and DNA photocleavage” (INOR 1200), at 2:30 p.m., Wednesday, March 28, at McCormick Place Lakeside room E253D by Virginia Tech Ph.D. chemistry student Ran Miao of Zhangzhou City, China. Co-authors are chemistry graduate students David F. Zigler of Sterling, Illinois, and Jared Brown of Salem, Va., and Brewer.
Susan Trulove | EurekAlert!
Making fuel out of thick air
08.12.2017 | DOE/Argonne National Laboratory
‘Spying’ on the hidden geometry of complex networks through machine intelligence
08.12.2017 | Technische Universität Dresden
The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.
Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...
With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong
Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...
An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications
Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...
Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.
The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...
Transistors based on carbon nanostructures: what sounds like a futuristic dream could be reality in just a few years' time. An international research team working with Empa has now succeeded in producing nanotransistors from graphene ribbons that are only a few atoms wide, as reported in the current issue of the trade journal "Nature Communications."
Graphene ribbons that are only a few atoms wide, so-called graphene nanoribbons, have special electrical properties that make them promising candidates for the...
08.12.2017 | Event News
07.12.2017 | Event News
05.12.2017 | Event News
08.12.2017 | Life Sciences
08.12.2017 | Information Technology
08.12.2017 | Information Technology